ENSMUSG00000037346


Mus musculus

Features
Gene ID: ENSMUSG00000037346
  
Biological name :Hrh4
  
Synonyms : Histamine H4 receptor / Hrh4 / Q91ZY2
  
Possible biological names infered from orthology : histamine receptor H4 / Q9H3N8
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 13006990
Gene end: 13022882
  
Corresponding Affymetrix probe sets: 10454052 (MoGene1.0st)   1426099_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041061
NCBI entrez gene - 225192     See in Manteia.
MGI - MGI:2429635
RefSeq - NM_153087
RefSeq Peptide - NP_694727
swissprot - Q91ZY2
Ensembl - ENSMUSG00000037346
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01084564.1ENSDARG00000045137Danio rerio
 LO017843.1ENSDARG00000103139Danio rerio
 HRH4ENSGALG00000026092Gallus gallus
 HRH4ENSG00000134489Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hrh3 / P58406 / Histamine H3 receptor / Q9Y5N1* / histamine receptor H3*ENSMUSG0000003905940
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615927
Chrm5 / Q920H4 / cholinergic receptor, muscarinic 5 / P08912*ENSMUSG0000007493925
Chrm1 / P12657 / cholinergic receptor, muscarinic 1, CNS / P11229* / cholinergic receptor muscarinic 1*ENSMUSG0000003277324
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300423
Chrm4 / P32211 / cholinergic receptor, muscarinic 4 / P08173*ENSMUSG0000004049523
Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*ENSMUSG0000004561322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR008102  Histamine H4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004969 histamine receptor activity IDA


Pathways (from Reactome)
Pathway description
Histamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr