ENSMUSG00000040495


Mus musculus

Features
Gene ID: ENSMUSG00000040495
  
Biological name :Chrm4
  
Synonyms : cholinergic receptor, muscarinic 4 / Chrm4 / P32211
  
Possible biological names infered from orthology : P08173
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E1
Gene start: 91927249
Gene end: 91928688
  
Corresponding Affymetrix probe sets: 10474002 (MoGene1.0st)   1450575_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040808
NCBI entrez gene - 12672     See in Manteia.
MGI - MGI:88399
RefSeq - NM_007699
RefSeq Peptide - NP_031725
swissprot - P32211
swissprot - Q0VBU3
Ensembl - ENSMUSG00000040495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm4aENSDARG00000069254Danio rerio
 CHRM4ENSGALG00000008365Gallus gallus
 CHRM4ENSG00000180720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*ENSMUSG0000004561357
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615945
Chrm5 / Q920H4 / cholinergic receptor, muscarinic 5 / P08912*ENSMUSG0000007493944
Chrm1 / P12657 / cholinergic receptor, muscarinic 1, CNS / P11229* / cholinergic receptor muscarinic 1*ENSMUSG0000003277341
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300426
Hrh3 / P58406 / Histamine H3 receptor / Q9Y5N1* / histamine receptor H3*ENSMUSG0000003905922
Hrh4 / Q91ZY2 / Histamine H4 receptor / Q9H3N8* / histamine receptor H4*ENSMUSG0000003734619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR001432  Muscarinic acetylcholine receptor M4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IDA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0040012 regulation of locomotion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity IDA


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

Allelic Composition: Chrm1tm1Jwe/Chrm1tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S6/SvEvTac * CF-1

Allelic Composition: Chrm2tm1Jwe/Chrm2tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * CF-1

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chrm1tm1Jwe/Chrm1tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S6/SvEvTac * CF-1

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrm2tm1Jwe/Chrm2tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * CF-1

 MP:0005085 abnormal gall bladder physiology "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrm4tm2.1Jwe/Chrm4tm2.1Jwe,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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