ENSMUSG00000039059


Mus musculus

Features
Gene ID: ENSMUSG00000039059
  
Biological name :Hrh3
  
Synonyms : Histamine H3 receptor / Hrh3 / P58406
  
Possible biological names infered from orthology : histamine receptor H3 / Q9Y5N1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 180099465
Gene end: 180104488
  
Corresponding Affymetrix probe sets: 10490378 (MoGene1.0st)   1448807_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049963
Ensembl peptide - ENSMUSP00000132203
Ensembl peptide - ENSMUSP00000130553
Ensembl peptide - ENSMUSP00000130181
Ensembl peptide - ENSMUSP00000127085
Ensembl peptide - ENSMUSP00000127053
Ensembl peptide - ENSMUSP00000126336
NCBI entrez gene - 99296     See in Manteia.
MGI - MGI:2139279
RefSeq - XM_017319357
RefSeq - NM_133849
RefSeq Peptide - NP_598610
swissprot - E9Q292
swissprot - E9PZM9
swissprot - E9Q5S3
swissprot - E9Q7T5
swissprot - P58406
swissprot - Q540P3
swissprot - E9Q522
swissprot - E9Q540
Ensembl - ENSMUSG00000039059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hrh3ENSDARG00000035942Danio rerio
 HRH3ENSGALG00000005170Gallus gallus
 HRH3ENSG00000101180Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hrh4 / Q91ZY2 / Histamine H4 receptor / Q9H3N8* / histamine receptor H4*ENSMUSG0000003734635
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615927
Chrm5 / Q920H4 / cholinergic receptor, muscarinic 5 / P08912*ENSMUSG0000007493927
Chrm1 / P12657 / cholinergic receptor, muscarinic 1, CNS / P11229* / cholinergic receptor muscarinic 1*ENSMUSG0000003277327
Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*ENSMUSG0000004561324
Chrm4 / P32211 / cholinergic receptor, muscarinic 4 / P08173*ENSMUSG0000004049524
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003980  Histamine H3 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IBA
 biological_processGO:0014050 negative regulation of glutamate secretion IBA
 biological_processGO:0014061 regulation of norepinephrine secretion IBA
 biological_processGO:0014063 negative regulation of serotonin secretion IBA
 biological_processGO:0050890 cognition IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004969 histamine receptor activity IEA


Pathways (from Reactome)
Pathway description
Histamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otcspf/Otc+
Genetic Background: Not Specified

Allelic Composition: Hrh3tm1Twl/Hrh3tm1Twl
Genetic Background: B6.129X1-Hrh3tm1Twl

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Hrh3+/?
Genetic Background: B10.S-H2s/SgMcdJ

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005447 abnormal synaptic norepinephrine release "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hrh4tm1Lex/Hrh4+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem,Tg(Tek-cre)#Rwng/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: Neurod1tm1Kan/Neurod1tm1Mjts
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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