MP:0000505 | reduced digestive secretion | "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Plp1jp-msd/Plp1jp-msd Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
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MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000538 | abnormal urinary bladder morphology | "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000539 | distended urinary bladder | "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000623 | reduced salivation | "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000740 | impaired smooth muscle contractility | "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0000741 | impaired contractility of detrusor smooth muscle | "inability or reduced ability of the detrusor smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000742 | impaired contractility of ileal smooth muscle | "inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: 129S6/SvEvTac-Chrm3tm1Jwe
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0001663 | abnormal digestive system physiology | "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd13spdh/Hoxd13spdh Genetic Background: B6C3Fe a/a-Hoxd13spdh/J
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MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: NanogGt(D047A12)Wrst/NanogGt(D047A12)Wrst Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0002503 | abnormal histamine physiology | "functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1jp-msd/Plp1jp-msd Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
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MP:0002546 | mydriasis | "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002696 | decreased circulating glucagon level | "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002711 | decreased glucagon secretion | "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Chrm3tm1Jwe/Chrm3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0002945 | abnormal inhibitory postsynaptic currents | "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Chrm3tm2Jwe/Chrm3tm2Jwe,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA
Allelic Composition: Chrm3tm1Jwe/Chrm3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0003194 | abnormal frequency of paradoxical sleep | "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0004994 | abnormal brain wave pattern | "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0005085 | abnormal gall bladder physiology | "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005534 | decreased body temperature | "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Chrm3tm2.1Jwe/Chrm3tm2.1Jwe,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N
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MP:0005591 | decreased vasodilation | "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0005668 | decreased circulating leptin level | "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0006243 | abnormal pupil dilation reaction to light | "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bcat2mpc91H/Bcat2mpc91H Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J
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MP:0009283 | decreased gonadal fat pad weight | "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: 129S6/SvEvTac-Chrm3tm1Jwe
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MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
Allelic Composition: Chrm3tm1Abt/Chrm3tm1Abt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0009456 | impaired cued conditioning behavior | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
Allelic Composition: Chrm3tm1Abt/Chrm3tm1Abt Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0010386 | abnormal urinary bladder physiology | "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac
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MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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MP:0011941 | increased fluid intake | "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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MP:0012125 | decreased bronchoconstrictive response | "reduction in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith] |
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Allelic Composition: Chrm3tm1Jwe/Chrm3tm1Jwe Genetic Background: involves: 129S6/SvEvTac * CF-1
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MP:0013300 | abnormal submandibular gland physiology | "any functional anomaly of either of the large major salivary glands situated beneath the mandible" [MGI:Anna] |
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Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm3tm1Mmt/Chrm3tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6
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