ENSMUSG00000032773


Mus musculus

Features
Gene ID: ENSMUSG00000032773
  
Biological name :Chrm1
  
Synonyms : cholinergic receptor, muscarinic 1, CNS / Chrm1 / P12657
  
Possible biological names infered from orthology : cholinergic receptor muscarinic 1 / P11229
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8663789
Gene end: 8683587
  
Corresponding Affymetrix probe sets: 10461143 (MoGene1.0st)   1439611_at (Mouse Genome 430 2.0 Array)   1450833_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042632
Ensembl peptide - ENSMUSP00000126103
Ensembl peptide - ENSMUSP00000135356
NCBI entrez gene - 12669     See in Manteia.
MGI - MGI:88396
RefSeq - NM_001112697
RefSeq - NM_007698
RefSeq Peptide - NP_001106167
RefSeq Peptide - NP_031724
swissprot - H3BKE3
swissprot - P12657
Ensembl - ENSMUSG00000032773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm1aENSDARG00000037292Danio rerio
 CHRM1ENSG00000168539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrm5 / Q920H4 / cholinergic receptor, muscarinic 5 / P08912*ENSMUSG0000007493956
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615955
Chrm4 / P32211 / cholinergic receptor, muscarinic 4 / P08173*ENSMUSG0000004049543
Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*ENSMUSG0000004561342
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300428
Hrh3 / P58406 / Histamine H3 receptor / Q9Y5N1* / histamine receptor H3*ENSMUSG0000003905926
Hrh4 / Q91ZY2 / Histamine H4 receptor / Q9H3N8* / histamine receptor H4*ENSMUSG0000003734620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR002228  Muscarinic acetylcholine receptor M1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003056 regulation of vascular smooth muscle contraction IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0040012 regulation of locomotion IMP
 biological_processGO:0043270 positive regulation of ion transport ISO
 biological_processGO:0046541 saliva secretion IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity IBA


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Festm1Pag/Festm1Pag,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Hoxb6tm1Cka/Hoxb6tm1Cka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chrm1tm1Stl/Chrm1+
Genetic Background: C57BL/6-Chrm1tm1Stl

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Chrm1tm1Stl/Chrm1+
Genetic Background: C57BL/6-Chrm1tm1Stl

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxb6tm1Cka/Hoxb6tm1Cka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ada/ada
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fgf17tm1Dor/Fgf17tm1Dor,Fgf8tm1.1Jyhl/Fgf8tm1.1Jyhl
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chrm1tm1Stl/Chrm1+
Genetic Background: C57BL/6-Chrm1tm1Stl

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chrm1tm1Jwe/Chrm1tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S6/SvEvTac * CF-1

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chrm1tm1Stl/Chrm1+
Genetic Background: C57BL/6-Chrm1tm1Stl

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Emx1tm1.1(cre)Ito/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Tg(Grik4-cre)G32-4Stl/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Festm1Pag/Festm1Pag,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004631 abnormal auditory cortex morphology "any structural abnormality in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrm1tm2.1Stl/Chrm1tm2.1Stl,Emx1tm1.1(cre)Ito/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004788 abnormal auditory cortex tonotopy "any abnormality in the spatial arrangement of structures that subserve various frequencies in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igkctm2(IGKC)Cgn/Igkctm2(IGKC)Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012124 increased bronchoconstrictive response "enhanced or greater than expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith]
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Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013300 abnormal submandibular gland physiology "any functional anomaly of either of the large major salivary glands situated beneath the mandible" [MGI:Anna]
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Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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