ENSMUSG00000045613


Mus musculus

Features
Gene ID: ENSMUSG00000045613
  
Biological name :Chrm2
  
Synonyms : cholinergic receptor, muscarinic 2, cardiac / Chrm2 / Q9ERZ4
  
Possible biological names infered from orthology : cholinergic receptor muscarinic 2 / P08172
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 36388084
Gene end: 36528414
  
Corresponding Affymetrix probe sets: 10537298 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000130874
NCBI entrez gene - 243764     See in Manteia.
MGI - MGI:88397
RefSeq - NM_203491
RefSeq - XM_006506136
RefSeq Peptide - NP_987076
swissprot - Q9ERZ4
Ensembl - ENSMUSG00000045613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm2aENSDARG00000098612Danio rerio
 chrm2bENSDARG00000116374Danio rerio
 CHRM2ENSGALG00000012894Gallus gallus
 CHRM2ENSG00000181072Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrm4 / P32211 / cholinergic receptor, muscarinic 4 / P08173*ENSMUSG0000004049559
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615945
Chrm5 / Q920H4 / cholinergic receptor, muscarinic 5 / P08912*ENSMUSG0000007493944
Chrm1 / P12657 / cholinergic receptor, muscarinic 1, CNS / P11229* / cholinergic receptor muscarinic 1*ENSMUSG0000003277341
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300425
Hrh3 / P58406 / Histamine H3 receptor / Q9Y5N1* / histamine receptor H3*ENSMUSG0000003905923
Hrh4 / Q91ZY2 / Histamine H4 receptor / Q9H3N8* / histamine receptor H4*ENSMUSG0000003734619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR001065  Muscarinic acetylcholine receptor M2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0008016 regulation of heart contraction IBA
 biological_processGO:0009615 response to virus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity ISS
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (i) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000742 impaired contractility of ileal smooth muscle "inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Chrm2tm1Jwe/Chrm2tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * CF-1

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrm2tm1Minm/Chrm2tm1Minm,Chrm3tm1Mmt/Chrm3tm1Mmt
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrm2tm1Jwe/Chrm2tm1Jwe,Chrm4tm1Jwe/Chrm4tm1Jwe
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * CF-1

 MP:0005085 abnormal gall bladder physiology "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Chrm2tm1Jwe/Chrm2+
Genetic Background: involves: 129S4/SvJae * CF-1

 MP:0012125 decreased bronchoconstrictive response "reduction in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith]
Show

Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / reaction / complex






 

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