ENSDARG00000098612


Danio rerio

Features
Gene ID: ENSDARG00000098612
  
Biological name :chrm2a
  
Synonyms : cholinergic receptor, muscarinic 2a / chrm2a
  
Possible biological names infered from orthology : cholinergic receptor muscarinic 2 / cholinergic receptor, muscarinic 2, cardiac / CHRM2 / P08172 / Q9ERZ4
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 1146346
Gene end: 1284672
  
Corresponding Affymetrix probe sets: Dr.24961.1.S1_at (Zebrafish Array)   NM_178301_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139587
Ensembl peptide - ENSDARP00000134707
NCBI entrez gene - 352938     See in Manteia.
RefSeq - NM_178301
RefSeq Peptide - NP_840086
swissprot - B3DKN8
ZFIN ID - ZDB-GENE-030314-1
Ensembl - ENSDARG00000098612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHRM2ENSGALG00000012894Gallus gallus
 CHRM2ENSG00000181072Homo sapiens
 Chrm2ENSMUSG00000045613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chrm4a / cholinergic receptor, muscarinic 4a / CHRM4* / P08173* / P32211* / cholinergic receptor muscarinic 4*ENSDARG0000006925459
chrm2b / cholinergic receptor, muscarinic 2b / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*ENSDARG0000011637458
si:ch73-151m17.5ENSDARG0000001772243
chrm5a / cholinergic receptor, muscarinic 5a / CHRM5* / P08912* / cholinergic receptor muscarinic 5*ENSDARG0000009992841
chrm3a / cholinergic receptor, muscarinic 3a / CHRM3* / Q9ERZ3* / P20309* / cholinergic receptor muscarinic 3* / cholinergic receptor, muscarinic 3, cardiac*ENSDARG0000007109140
chrm3b / cholinergic receptor, muscarinic 3b / CHRM3* / Q9ERZ3* / P20309* / cholinergic receptor muscarinic 3* / cholinergic receptor, muscarinic 3, cardiac*ENSDARG0000007129839
chrm5b / cholinergic receptor, muscarinic 5b / CHRM5* / P08912* / Q920H4* / cholinergic receptor muscarinic 5*ENSDARG0000006959838
chrm1a / cholinergic receptor, muscarinic 1a / CHRM1* / P12657* / P11229* / cholinergic receptor muscarinic 1* / cholinergic receptor, muscarinic 1, CNS*ENSDARG0000003729237
hrh3 / histamine receptor H3 / P58406* / Q9Y5N1* / Histamine H3 receptor *ENSDARG0000003594223
LO017843.1 / HRH4* / Q9H3N8* / histamine receptor H4*ENSDARG0000010313921
CABZ01084564.1 / HRH4* / Q9H3N8* / histamine receptor H4*ENSDARG0000004513719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000995  Muscarinic acetylcholine receptor family
 IPR001065  Muscarinic acetylcholine receptor M2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0010459 negative regulation of heart rate IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity IBA


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (i) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / reaction / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex / reaction






 

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