ENSMUSG00000074939


Mus musculus

Features
Gene ID: ENSMUSG00000074939
  
Biological name :Chrm5
  
Synonyms : cholinergic receptor, muscarinic 5 / Chrm5 / Q920H4
  
Possible biological names infered from orthology : P08912
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E3
Gene start: 112479171
Gene end: 112480769
  
Corresponding Affymetrix probe sets: 10485836 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000097185
NCBI entrez gene - 213788     See in Manteia.
MGI - MGI:109248
RefSeq - NM_205783
RefSeq - XM_006499099
RefSeq Peptide - NP_991352
swissprot - Q920H4
Ensembl - ENSMUSG00000074939
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrm5aENSDARG00000099928Danio rerio
 chrm5bENSDARG00000069598Danio rerio
 CHRM5ENSGALG00000009640Gallus gallus
 CHRM5ENSG00000184984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrm3 / Q9ERZ3 / cholinergic receptor, muscarinic 3, cardiac / P20309* / cholinergic receptor muscarinic 3*ENSMUSG0000004615952
Chrm1 / P12657 / cholinergic receptor, muscarinic 1, CNS / P11229* / cholinergic receptor muscarinic 1*ENSMUSG0000003277349
Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*ENSMUSG0000004561339
Chrm4 / P32211 / cholinergic receptor, muscarinic 4 / P08173*ENSMUSG0000004049539
Hrh1 / P70174 / Histamine H1 receptor / P35367* / histamine receptor H1*ENSMUSG0000005300423
Hrh3 / P58406 / Histamine H3 receptor / Q9Y5N1* / histamine receptor H3*ENSMUSG0000003905922
Hrh4 / Q91ZY2 / Histamine H4 receptor / Q9H3N8* / histamine receptor H4*ENSMUSG0000003734618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000502  Muscarinic acetylcholine receptor M5
 IPR000995  Muscarinic acetylcholine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
 biological_processGO:0007271 synaptic transmission, cholinergic IBA
 biological_processGO:0015872 dopamine transport IDA
 biological_processGO:0019226 transmission of nerve impulse IDA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060304 regulation of phosphatidylinositol dephosphorylation IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IBA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016907 G-protein coupled acetylcholine receptor activity IBA
 molecular_functionGO:0016934 extracellularly glycine-gated chloride channel activity TAS


Pathways (from Reactome)
Pathway description
Muscarinic acetylcholine receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Chrm1tm1Kano/Chrm1tm1Kano,Chrm5tm1Minm/Chrm5tm1Minm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dysftm1Kcam/Dysftm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0002503 abnormal histamine physiology "functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

 MP:0005111 hyperdipsia "intense thirst that is relatively temporary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83217]
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Allelic Composition: Dysftm1Kcam/Dysftm1Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

Allelic Composition: Chrm5tm1Jwe/Chrm5tm1Jwe
Genetic Background: B6.129S6-Chrm5tm1Jwe

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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