| MP:0000005 | increased brown fat amount | "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0000008 | increased white fat amount | "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0001417 | decreased exploration in new environment | "less amount of time spent investigating a new location" [J:79870] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
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| MP:0001806 | decreased IgM | "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0001876 | decreased inflammatory response | "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
Allelic Composition: Hrh1Bphs-r/Hrh1Bphs-s
Genetic Background: (C3H/HeJ x SJL/J)F1
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| MP:0002493 | increased IgG | "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0003638 | abnormal response/metabolism to endogenous compounds | "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0005025 | response to infection | "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
Allelic Composition: Hrh1Bphs-r/Hrh1Bphs-s
Genetic Background: (C3H/HeJ x SJL/J)F1
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| MP:0005093 | impaired B cell proliferation | "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0005317 | increased triglyceride level | "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0006094 | adipocyte hypertrophy | "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802] |
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Allelic Composition: Cd8a/Cd8b1tm3Welm/Cd8a/Cd8b1tm3Welm
Genetic Background: involves: 129 * C57BL/6
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| MP:0008498 | decreased IgG3 level | "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008567 | decreased interferon-gamma secretion | "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0008673 | decreased interleukin-13 secretion | "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0008688 | decreased interleukin-2 secretion | "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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| MP:0008703 | decreased interleukin-5 secretion | "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tulp1tvrm124/Tulp1tvrm124
Genetic Background: involves: C57BL/6J
Allelic Composition: Hrh1Bphs-r/Hrh1Bphs-s
Genetic Background: (C3H/HeJ x SJL/J)F1
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| MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0011940 | decreased food intake | "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0011943 | abnormal circadian feeding behavior | "anomaly in the fluctuation pattern in feeding behavior (amount and instances) that occurs over an approximately 24 hour light/dark cycle" [MGI:csmith] |
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Allelic Composition: Hrh1tm1Wtn/Hrh1tm1Wtn
Genetic Background: B6.129P2-Hrh1tm1Wtn
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| MP:0020477 | abnormal locomotor circadian rhythm | "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475] |
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac
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