Homo sapiens

Gene ID: ENSG00000137486
Biological name :ARRB1
Synonyms : ARRB1 / arrestin beta 1 / P49407
Possible biological names infered from orthology :
Species: Homo sapiens
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 75264182
Gene end: 75351705
Corresponding Affymetrix probe sets: 218832_x_at (Human Genome U133 Plus 2.0 Array)   222756_s_at (Human Genome U133 Plus 2.0 Array)   222912_at (Human Genome U133 Plus 2.0 Array)   228444_at (Human Genome U133 Plus 2.0 Array)   
Cross references: Ensembl peptide - ENSP00000436352
Ensembl peptide - ENSP00000434196
Ensembl peptide - ENSP00000436530
Ensembl peptide - ENSP00000353124
Ensembl peptide - ENSP00000409581
Ensembl peptide - ENSP00000433137
Ensembl peptide - ENSP00000433171
NCBI entrez gene - 408     See in Manteia.
OMIM - 107940
RefSeq - XM_017017754
RefSeq - NM_004041
RefSeq - NM_020251
RefSeq - XM_011545034
RefSeq - XM_011545035
RefSeq - XM_017017750
RefSeq - XM_017017751
RefSeq - XM_017017752
RefSeq - XM_017017753
RefSeq Peptide - NP_004032
RefSeq Peptide - NP_064647
swissprot - H0YEQ2
swissprot - H0YET9
swissprot - H0YD81
swissprot - E9PM35
swissprot - P49407
swissprot - H0YDS1
Ensembl - ENSG00000137486
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrb1ENSDARG00000043241Danio rerio
 Arrb1ENSMUSG00000018909Mus musculus

Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARRB2 / P32121 / arrestin beta 2ENSG0000014148075
SAG / P10523 / S-antigen visual arrestinENSG0000013056155
ARR3 / P36575 / arrestin 3ENSG0000012050055

Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site

Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002031 G-protein coupled receptor internalization IMP
 biological_processGO:0002092 positive regulation of receptor internalization IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007602 phototransduction IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032717 negative regulation of interleukin-8 production IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034393 positive regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IMP
 biological_processGO:0035066 positive regulation of histone acetylation IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043149 stress fiber assembly IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0090240 positive regulation of histone H4 acetylation IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004857 enzyme inhibitor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IMP
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031691 alpha-1A adrenergic receptor binding IEA
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding IEA
 molecular_functionGO:0031701 angiotensin receptor binding IPI
 molecular_functionGO:0031762 follicle-stimulating hormone receptor binding IEA
 molecular_functionGO:0031896 V2 vasopressin receptor binding IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IPI

Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match

Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / complex / reaction
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / reaction / complex
 ENSG00000135144 DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex
 ENSG00000148400 NOTCH1 / P46531  / complex / reaction
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex / reaction
 ENSG00000181072 CHRM2 / P08172 / cholinergic receptor muscarinic 2  / reaction / complex
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction / complex
 ENSG00000126895 AVPR2 / P30518 / arginine vasopressin receptor 2  / reaction / complex
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000101200 AVP / P01185 / arginine vasopressin  / reaction / complex
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction


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