ENSG00000131437


Homo sapiens

Features
Gene ID: ENSG00000131437
  
Biological name :KIF3A
  
Synonyms : KIF3A / kinesin family member 3A / Q9Y496
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 132692628
Gene end: 132737638
  
Corresponding Affymetrix probe sets: 213623_at (Human Genome U133 Plus 2.0 Array)   228680_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385808
Ensembl peptide - ENSP00000368020
Ensembl peptide - ENSP00000391863
Ensembl peptide - ENSP00000483023
Ensembl peptide - ENSP00000405619
Ensembl peptide - ENSP00000368009
NCBI entrez gene - 11127     See in Manteia.
OMIM - 604683
RefSeq - XM_017008996
RefSeq - NM_001300791
RefSeq - NM_001300792
RefSeq - NM_007054
RefSeq - XM_006714526
RefSeq - XM_017008995
RefSeq Peptide - NP_001287720
RefSeq Peptide - NP_001287721
RefSeq Peptide - NP_008985
swissprot - C9J9X2
swissprot - H7C2F6
swissprot - J3KPF9
swissprot - E9PES4
swissprot - A0A087X011
swissprot - Q9Y496
Ensembl - ENSG00000131437
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kif3aENSDARG00000087538Danio rerio
 KIF3AENSGALG00000006860Gallus gallus
 Kif3aENSMUSG00000018395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KIF3B / O15066 / kinesin family member 3BENSG0000010135048
KIF3C / O14782 / kinesin family member 3CENSG0000008473144
KIF17 / Q9P2E2 / kinesin family member 17ENSG0000011724541
KIF11 / P52732 / kinesin family member 11ENSG0000013816033
KIF4B / Q2VIQ3 / kinesin family member 4BENSG0000022665031
CENPE / Q02224 / centromere protein EENSG0000013877831
KIF15 / Q9NS87 / kinesin family member 15ENSG0000016380830
KIF4A / O95239 / kinesin family member 4AENSG0000009088930
KIF5A / Q12840 / kinesin family member 5AENSG0000015598029
KIF27 / Q86VH2 / kinesin family member 27ENSG0000016511529
KIF21A / Q7Z4S6 / kinesin family member 21AENSG0000013911629
KIF5C / O60282 / kinesin family member 5CENSG0000016828028
KIF7 / Q2M1P5 / kinesin family member 7ENSG0000016681328
KIF5B / P33176 / kinesin family member 5BENSG0000017075928
KIF21B / O75037 / kinesin family member 21BENSG0000011685228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001752  Kinesin motor domain
 IPR019821  Kinesin motor domain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027640  Kinesin-like protein
 IPR036961  Kinesin motor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0006996 organelle organization TAS
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0010457 centriole-centriole cohesion IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0021542 dentate gyrus development IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0034454 microtubule anchoring at centrosome IEA
 biological_processGO:0035735 intraciliary transport involved in cilium assembly TAS
 biological_processGO:0036334 epidermal stem cell homeostasis IEA
 biological_processGO:0044458 motile cilium assembly IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0061351 neural precursor cell proliferation IEA
 biological_processGO:0072383 plus-end-directed vesicle transport along microtubule TAS
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 biological_processGO:1905128 positive regulation of axo-dendritic protein transport IEA
 biological_processGO:1905515 non-motile cilium assembly IEA
 biological_processGO:2000771 positive regulation of establishment or maintenance of cell polarity regulating cell shape IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016939 kinesin II complex IEA
 cellular_componentGO:0030990 intraciliary transport particle IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097470 ribbon synapse IEA
 cellular_componentGO:0097542 ciliary tip TAS
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed TAS
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030507 spectrin binding IDA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MHC class II antigen presentation
Hedgehog off state
Intraflagellar transport
Activation of SMO
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / reaction / complex
 ENSG00000084731 KIF3C / O14782 / kinesin family member 3C  / complex / reaction
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000109083 IFT20 / Q8IY31 / intraflagellar transport 20  / reaction / complex
 ENSG00000075945 KIFAP3 / Q92845 / kinesin associated protein 3  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / reaction / complex
 ENSG00000101350 KIF3B / O15066 / kinesin family member 3B  / reaction / complex
 ENSG00000168118 RAB4A / P20338 / RAB4A, member RAS oncogene family  / reaction / complex
 ENSG00000131437 KIF3A / Q9Y496 / kinesin family member 3A  / complex / reaction






 

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