ENSG00000161203


Homo sapiens

Features
Gene ID: ENSG00000161203
  
Biological name :AP2M1
  
Synonyms : adaptor related protein complex 2 mu 1 subunit / AP2M1 / Q96CW1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.1
Gene start: 184174689
Gene end: 184184091
  
Corresponding Affymetrix probe sets: 200613_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395438
Ensembl peptide - ENSP00000481563
Ensembl peptide - ENSP00000416688
Ensembl peptide - ENSP00000409081
Ensembl peptide - ENSP00000404326
Ensembl peptide - ENSP00000404031
Ensembl peptide - ENSP00000403362
Ensembl peptide - ENSP00000402592
Ensembl peptide - ENSP00000402051
Ensembl peptide - ENSP00000292807
Ensembl peptide - ENSP00000371894
NCBI entrez gene - 1173     See in Manteia.
OMIM - 601024
RefSeq - NM_001311198
RefSeq - NM_004068
RefSeq - NM_001025205
RefSeq Peptide - NP_001020376
RefSeq Peptide - NP_001298127
RefSeq Peptide - NP_004059
swissprot - H7C4C3
swissprot - E9PFW3
swissprot - Q96CW1
swissprot - C9JTK4
swissprot - C9JPV8
swissprot - C9JJD3
swissprot - C9JJ47
swissprot - C9JGT8
swissprot - A0A087WY71
Ensembl - ENSG00000161203
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2m1aENSDARG00000002790Danio rerio
 ap2m1bENSDARG00000033899Danio rerio
 AP2M1ENSGALG00000008432Gallus gallus
 Ap2m1ENSMUSG00000022841Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunitENSG0000012935437
AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunitENSG0000007295837
AP4M1 / O00189 / adaptor related protein complex 4 mu 1 subunitENSG0000022183827
AP3M2 / P53677 / adaptor related protein complex 3 mu 2 subunitENSG0000007071824
AP3M1 / Q9Y2T2 / adaptor related protein complex 3 mu 1 subunitENSG0000018500923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016050 vesicle organization IMP
 biological_processGO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0032802 low-density lipoprotein particle receptor catabolic process TAS
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072583 clathrin-dependent endocytosis TAS
 biological_processGO:0097494 regulation of vesicle size IMP
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex TAS
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005048 signal sequence binding IDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity TAS
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISS
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Nef mediated downregulation of CD28 cell surface expression
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000100246 DNAL4 / O96015 / dynein axonemal light chain 4  / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / reaction / complex
 ENSG00000114251 WNT5A / P41221 / Wnt family member 5A  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000120251 GRIA2 / P42262 / glutamate ionotropic receptor AMPA type subunit 2  / reaction
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / reaction / complex
 ENSG00000155511 GRIA1 / P42261 / glutamate ionotropic receptor AMPA type subunit 1  / reaction
 ENSG00000152578 GRIA4 / P48058 / glutamate ionotropic receptor AMPA type subunit 4  / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex / reaction
 ENSG00000100151 PICK1 / Q9NRD5 / protein interacting with PRKCA 1  / reaction
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / complex / reaction
 ENSG00000153071 DAB2 / P98082 / DAB2, clathrin adaptor protein  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / complex / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000169174 PCSK9 / Q8NBP7 / proprotein convertase subtilisin/kexin type 9  / reaction / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000196586 MYO6 / Q9UM54 / myosin VI  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000147852 VLDLR / P98155 / very low density lipoprotein receptor  / reaction / complex
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000130164 LDLR / P01130 / low density lipoprotein receptor  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / complex / reaction
 ENSG00000178562 CD28 / P10747 / CD28 molecule  / complex / reaction
 ENSG00000172116 CD8B / P10966 / CD8b molecule  / reaction / complex
 ENSG00000047249 Q9UI12 / ATP6V1H / ATPase H+ transporting V1 subunit H  / reaction / complex
 ENSG00000155974 GRIP1 / Q9Y3R0 / glutamate receptor interacting protein 1  / reaction
 ENSG00000090889 KIF4A / O95239 / kinesin family member 4A  / complex / reaction
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex / reaction
 ENSG00000226650 KIF4B / Q2VIQ3 / kinesin family member 4B  / reaction / complex
 ENSG00000125675 GRIA3 / P42263 / glutamate ionotropic receptor AMPA type subunit 3  / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / reaction / complex






 

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