ENSDARG00000002790


Danio rerio

Features
Gene ID: ENSDARG00000002790
  
Biological name :ap2m1b
  
Synonyms : adaptor-related protein complex 2, mu 1 subunit, b / ap2m1a / ap2m1b / Q6NWK2
  
Possible biological names infered from orthology : adaptor related protein complex 2 mu 1 subunit / AP-2 complex subunit mu / AP2M1 / P84091 / Q96CW1
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 9789811
Gene end: 9818711
  
Corresponding Affymetrix probe sets: Dr.2385.1.S1_at (Zebrafish Array)   NM_212577_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000010193
Ensembl peptide - ENSDARP00000106819
Ensembl peptide - ENSDARP00000118560
Ensembl peptide - ENSDARP00000120773
Ensembl peptide - ENSDARP00000136644
Ensembl peptide - ENSDARP00000046586
NCBI entrez gene - 321051     See in Manteia.
RefSeq - NM_001291355
RefSeq - NM_212577
RefSeq Peptide - NP_001278284
RefSeq Peptide - NP_997742
swissprot - F1Q9V1
swissprot - A0A0R4IL09
swissprot - A8E7K7
swissprot - F1QLI6
swissprot - G1K2F5
swissprot - Q6NWK2
ZFIN ID - ZDB-GENE-030131-9784
ZFIN ID - ZDB-GENE-040426-1103
Ensembl - ENSDARG00000002790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP2M1ENSGALG00000008432Gallus gallus
 AP2M1ENSG00000161203Homo sapiens
 Ap2m1ENSMUSG00000022841Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*ENSDARG0000003389998
ap1m3 / adaptor-related protein complex 1, mu 3 subunitENSDARG0000003951239
ap1m1 / adaptor-related protein complex 1, mu 1 subunit / Q9BXS5*ENSDARG0000009624938
ap1m2 / adaptor-related protein complex 1, mu 2 subunit / Q9Y6Q5*ENSDARG0000009645438
ap3m1 / adaptor-related protein complex 3, mu 1 subunit / Q9JKC8* / Q9Y2T2* / AP-3 complex subunit mu-1 *ENSDARG0000002992826
ap4m1 / adaptor-related protein complex 4, mu 1 subunit / O00189* / Q9JKC7* / AP-4 complex subunit mu-1 *ENSDARG0000005687126
ap3m2 / adaptor-related protein complex 3, mu 2 subunit / P53677* / Q8R2R9* / AP-3 complex subunit mu-2 *ENSDARG0000001612824
LO018011.1 / AP1M2* / Q9Y6Q5* / adaptor related protein complex 1 mu 2 subunit*ENSDARG0000011393219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic process increased process quality , abnormal
Show

 ZFA:0000092 axis axis increased width , abnormal
axis shortened , abnormal
Show

 ZFA:0000155 somite somite deformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000043510 vamp4 / vesicle-associated membrane protein 4 / O70480* / O75379*  / complex / reaction
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / reaction / complex
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSDARG00000037498 gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032737 gria3a / glutamate receptor, ionotropic, AMPA 3a / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000015053 grip1 / glutamate receptor interacting protein 1 / Q925T6* / Q9Y3R0*  / reaction
 ENSDARG00000032714 gria1b / glutamate receptor, ionotropic, AMPA 1b / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000074185 pcsk9 / proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000031116 dnal4a / dynein, axonemal, light chain 4a / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000088841 dnal4b / dynein, axonemal, light chain 4b / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000052368 cltb / clathrin, light chain B / P09497* / Q6IRU5*  / complex / reaction






 

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