ENSDARG00000009087


Danio rerio

Features
Gene ID: ENSDARG00000009087
  
Biological name :cd74a
  
Synonyms : cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a
  
Possible biological names infered from orthology : CD74 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / CD74 molecule / P04233 / P04441
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 3038473
Gene end: 3052361
  
Corresponding Affymetrix probe sets: Dr.7740.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000002547
Ensembl peptide - ENSDARP00000124614
Ensembl peptide - ENSDARP00000124682
NCBI entrez gene - 58113     See in Manteia.
swissprot - F8W2L8
swissprot - F8W2T5
swissprot - Q9PUT2
ZFIN ID - ZDB-GENE-000901-1
Ensembl - ENSDARG00000009087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD74ENSGALG00000004594Gallus gallus
 CD74ENSG00000019582Homo sapiens
 Cd74ENSMUSG00000024610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR015386  MHC class II-associated invariant chain/CLIP, MHC II-interacting


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IDA
 biological_processGO:0002468 dendritic cell antigen processing and presentation IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0048839 inner ear development IGI
 biological_processGO:0048884 neuromast development IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042289 MHC class II protein binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009065 endothelial cell endothelial cell apoptotic process increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / reaction / complex
 ENSDARG00000027966 ap1s3b / adaptor-related protein complex 1, sigma 3 subunit, b / AP1S3* / Q96PC3* / Q7TN05* / AP-1 complex subunit sigma-3 * / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000054807 sec13 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735* / Q9D1M0*  / complex / reaction
 ENSDARG00000104375 sec24a / SEC24 homolog A, COPII coat complex component / O95486*  / complex / reaction
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000096454 ap1m2 / adaptor-related protein complex 1, mu 2 subunit / Q9Y6Q5*  / complex
 ENSDARG00000096249 ap1m1 / adaptor-related protein complex 1, mu 1 subunit / Q9BXS5*  / complex
 ENSDARG00000103403 sar1b / secretion associated, Ras related GTPase 1B / Q9Y6B6*  / reaction / complex
 ENSDARG00000103516 sec24c / SEC24 homolog C, COPII coat complex component / P53992* / Sec24 related gene family, member C (S. cerevisiae)*  / reaction / complex
 ENSDARG00000071336 mif / macrophage migration inhibitory factor / P14174* / P34884* / macrophage migration inhibitory factor (glycosylation-inhibiting factor)*  / reaction / complex
 ENSDARG00000021082 sec31a / SEC31 homolog A, COPII coat complex component / O94979* / Q3UPL0* / Protein transport protein Sec31A *  / reaction / complex
 ENSDARG00000071906 sec24b / SEC24 homolog B, COPII coat complex component / O95487* / Sec24 related gene family, member B (S. cerevisiae)*  / complex / reaction
 ENSDARG00000110439 ap1s3a / adaptor-related protein complex 1, sigma 3 subunit, a / AP1S3* / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSDARG00000104230 Q7SZE5 / sec23a / Sec23 homolog A, COPII coat complex component / Q15436* / Q01405* / Protein transport protein Sec23A * / Sec23 homolog A, coat complex II component*  / reaction / complex
 ENSDARG00000020621 ap1b1 / adaptor-related protein complex 1, beta 1 subunit / O35643* / Q10567* / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA.*  / complex
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000056803 ap1s1 / adaptor-related protein complex 1, sigma 1 subunit / P61966* / P61967* / AP-1 complex subunit sigma-1A *  / complex
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSDARG00000037488 canx / calnexin / P27824* / P35564*  / complex / reaction
 ENSDARG00000074656 ctss2.1 / cathepsin S, ortholog2, tandem duplicate 1 / CTSS* / O70370* / P25774* / cathepsin S*  / reaction






 

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