ENSGALG00000004594


Gallus gallus

Features
Gene ID: ENSGALG00000004594
  
Biological name :CD74
  
Synonyms : CD74 / CD74 molecule
  
Possible biological names infered from orthology : CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233 / P04441
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 13146841
Gene end: 13150694
  
Corresponding Affymetrix probe sets: Gga.4414.1.S1_s_at (Chicken Array)   Gga.4414.3.S1_a_at (Chicken Array)   GgaAffx.21845.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063230
Ensembl peptide - ENSGALP00000007299
Ensembl peptide - ENSGALP00000039736
NCBI entrez gene - 414741     See in Manteia.
RefSeq - XM_015293754
RefSeq - NM_001001613
RefSeq Peptide - NP_001001613
swissprot - A0A1L1RWL6
swissprot - Q6J613
swissprot - F1NYL5
Ensembl - ENSGALG00000004594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd74aENSDARG00000009087Danio rerio
 CD74ENSG00000019582Homo sapiens
 Cd74ENSMUSG00000024610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR011988  MHC class II-associated invariant chain, trimerisation
 IPR015386  MHC class II-associated invariant chain/CLIP, MHC II-interacting
 IPR022339  MHC class II-associated invariant chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA
 biological_processGO:0002792 negative regulation of peptide secretion IEA
 biological_processGO:0002830 positive regulation of type 2 immune response IEA
 biological_processGO:0002906 negative regulation of mature B cell apoptotic process IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0035691 macrophage migration inhibitory factor signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045657 positive regulation of monocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IEA
 biological_processGO:0070206 protein trimerization IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0035692 macrophage migration inhibitory factor receptor complex IEA
 cellular_componentGO:0035693 NOS2-CD74 complex IEA
 cellular_componentGO:0042611 MHC protein complex IDA
 cellular_componentGO:0042613 MHC class II protein complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding IEA
 molecular_functionGO:0035718 macrophage migration inhibitory factor binding IDA
 molecular_functionGO:0042288 MHC class I protein binding IPI
 molecular_functionGO:0042289 MHC class II protein binding IEA
 molecular_functionGO:0042609 CD4 receptor binding IEA
 molecular_functionGO:0042658 MHC class II protein binding, via antigen binding groove IEA
 molecular_functionGO:0044183 protein binding involved in protein folding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005171 AP1S3 / adaptor related protein complex 1 sigma 3 subunit / Q7TN05* / Q96PC3* / AP-1 complex subunit sigma-3 *  / complex
 ENSGALG00000004594 CD74 / CD74 molecule / P04233* / P04441* / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)*  / complex
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSGALG00000006326 MIF / Q02960 / Macrophage migration inhibitory factor / P14174* / P34884* / macrophage migration inhibitory factor (glycosylation-inhibiting factor)*  / complex / reaction
 ENSGALG00000016551 AP1S2 / AP-1 complex subunit sigma-2 / P56377* / Q9DB50* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSGALG00000042213 AP1B1 / adaptor related protein complex 1 beta 1 subunit / O35643* / Q10567* / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA.*  / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex
 ENSGALG00000008419 SEC13 / P55735* / Q9D1M0* / SEC13 homolog, nuclear pore and COPII coat complex component*  / complex
 ENSGALG00000006417 SEC24A / Gallus gallus SEC24 homolog A, COPII coat complex component (SEC24A), mRNA. / O95486* / Q3U2P1* / Protein transport protein Sec24A * / SEC24 homolog A, COPII coat complex component*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000010150 SEC23A / Sec23 homolog A, coat complex II component / Q01405* / Q15436* / Protein transport protein Sec23A *  / complex
 ENSGALG00000011998 SEC24D / SEC24 homolog D, COPII coat complex component / O94855* / Sec24 related gene family, member D (S. cerevisiae)*  / complex
 ENSGALG00000038753 SAR1B / GTP-binding protein SAR1b / Q9CQC9* / Q9Y6B6* / secretion associated Ras related GTPase 1B*  / complex
 ENSGALG00000040484 SEC31A / protein transport protein Sec31A / O94979* / Q3UPL0* / SEC31 homolog A, COPII coat complex component*  / complex
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

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