ENSGALG00000005139


Gallus gallus

Features
Gene ID: ENSGALG00000005139
  
Biological name :CLTC
  
Synonyms : clathrin heavy chain / CLTC
  
Possible biological names infered from orthology : Q00610
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7287318
Gene end: 7316659
  
Corresponding Affymetrix probe sets: Gga.2120.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052646
Ensembl peptide - ENSGALP00000008236
NCBI entrez gene - 395272     See in Manteia.
RefSeq - XM_015295663
RefSeq - NM_001080117
RefSeq Peptide - NP_001073586
swissprot - A0A1D5PIL2
swissprot - F1NW23
Ensembl - ENSGALG00000005139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cltcbENSDARG00000090716Danio rerio
 CLTCENSG00000141367Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLTCL1 / clathrin heavy chain like 1 / P53675*ENSGALG0000004176088


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015348  Clathrin, heavy chain, linker, core motif
 IPR016024  Armadillo-type fold
 IPR016025  Clathrin heavy chain, N-terminal
 IPR016341  Clathrin, heavy chain
 IPR022365  Clathrin, heavy chain, propeller repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0048268 clathrin coat assembly IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030130 clathrin coat of trans-Golgi network vesicle IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0071439 clathrin complex IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0032051 clathrin light chain binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003344 CLTB / clathrin light chain B / P09497* / Q6IRU5*  / complex
 ENSGALG00000004594 CD74 / CD74 molecule / P04233* / P04441* / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)*  / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / reaction / complex
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / reaction / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSGALG00000034168 WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*  / complex
 ENSGALG00000016551 AP1S2 / AP-1 complex subunit sigma-2 / P56377* / Q9DB50* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / reaction / complex
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000042213 AP1B1 / adaptor related protein complex 1 beta 1 subunit / O35643* / Q10567* / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA.*  / complex
 ENSGALG00000005171 AP1S3 / adaptor related protein complex 1 sigma 3 subunit / Q7TN05* / Q96PC3* / AP-1 complex subunit sigma-3 *  / complex
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex
 ENSGALG00000010166 VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*  / complex
 ENSGALG00000014853 CLVS2 / clavesin 2 / Q5SYC1* / Q8BG92*  / complex
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction






 

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