ENSGALG00000002556


Gallus gallus

Features
Gene ID: ENSGALG00000002556
  
Biological name :NGF
  
Synonyms : nerve growth factor / NGF
  
Possible biological names infered from orthology : Beta-nerve growth factor / P01138 / P01139
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 4027896
Gene end: 4047968
  
Corresponding Affymetrix probe sets: Gga.5163.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047700
Ensembl peptide - ENSGALP00000004030
NCBI entrez gene - 396466     See in Manteia.
RefSeq - XM_015298897
RefSeq - NM_001293108
RefSeq - NM_001293109
RefSeq Peptide - NP_001280037
RefSeq Peptide - NP_001280038
swissprot - A0A140T8F7
Ensembl - ENSGALG00000002556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfaENSDARG00000058961Danio rerio
 ngfbENSDARG00000014050Danio rerio
 NGFENSG00000134259Homo sapiens
 NgfENSMUSG00000027859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTF3 / neurotrophin 3 / P20181* / P20783*ENSGALG0000002729938
BDNF / P25429 / Brain-derived neurotrophic factor / P21237* / P23560*ENSGALG0000001216336


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020425  Nerve growth factor, beta subunit
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005163 nerve growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
NGF processing
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
PI3K/AKT activation
NFG and proNGF binds to p75NTR
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex
 ENSGALG00000009364 PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*  / reaction / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / reaction / complex
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / reaction / complex
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008443 ARHGDIA / rho GDP-dissociation inhibitor 1 / P52565* / Q99PT1* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000006390 CRKL / CRK like proto-oncogene, adaptor protein / P46109* / P47941* / Crk-like protein *  / complex
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction
 ENSGALG00000033256 PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

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