ENSGALG00000012163


Gallus gallus

Features
Gene ID: ENSGALG00000012163
  
Biological name :BDNF
  
Synonyms : BDNF / Brain-derived neurotrophic factor / P25429
  
Possible biological names infered from orthology : P21237 / P23560
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 3715527
Gene end: 3747234
  
Corresponding Affymetrix probe sets: Gga.696.1.A1_at (Chicken Array)   Gga.696.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019837
Ensembl peptide - ENSGALP00000063414
Ensembl peptide - ENSGALP00000063948
NCBI entrez gene - 396186     See in Manteia.
RefSeq - XM_015286154
RefSeq - NM_001031616
RefSeq - XM_015286151
RefSeq - XM_015286152
RefSeq - XM_015286153
RefSeq Peptide - NP_001026787
swissprot - P25429
swissprot - K4MNE5
Ensembl - ENSGALG00000012163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bdnfENSDARG00000018817Danio rerio
 BDNFENSG00000176697Homo sapiens
 BdnfENSMUSG00000048482Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTF3 / neurotrophin 3 / P20181* / P20783*ENSGALG0000002729938
NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *ENSGALG0000000255635


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020430  Brain-derived neurotrophic factor
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007416 synapse assembly IEA
 biological_processGO:0009408 response to heat IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048668 collateral sprouting IEA
 biological_processGO:0048672 positive regulation of collateral sprouting IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005169 neurotrophin TRKB receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex
 ENSGALG00000012163 BDNF / P25429 / Brain-derived neurotrophic factor / P21237* / P23560*  / complex
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000012594 NTRK2 / Q91987 / BDNF/NT-3 growth factors receptor / P15209* / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr