ENSGALG00000012594


Gallus gallus

Features
Gene ID: ENSGALG00000012594
  
Biological name :NTRK2
  
Synonyms : BDNF/NT-3 growth factors receptor / NTRK2 / Q91987
  
Possible biological names infered from orthology : neurotrophic receptor tyrosine kinase 2 / P15209 / Q16620
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 40289647
Gene end: 40495033
  
Corresponding Affymetrix probe sets: Gga.681.1.S1_at (Chicken Array)   Gga.681.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020539
Ensembl peptide - ENSGALP00000062213
NCBI entrez gene - 396157     See in Manteia.
RefSeq - XM_015280257
RefSeq - NM_205231
RefSeq - XM_015280255
RefSeq - XM_015280256
RefSeq - XM_015280249
RefSeq - XM_015280251
RefSeq - XM_015280252
RefSeq - XM_015280253
RefSeq - XM_015280254
RefSeq Peptide - NP_990562
swissprot - Q91987
Ensembl - ENSGALG00000012594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntrk2aENSDARG00000059897Danio rerio
 ntrk2bENSDARG00000098511Danio rerio
 NTRK2ENSG00000148053Homo sapiens
 Ntrk2ENSMUSG00000055254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*ENSGALG0000004024155
NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSGALG0000001901948
MUSK / muscle, skeletal receptor tyrosine protein kinase precursor / O15146* / Q61006* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSGALG0000001572827
INSR / insulin receptor / P06213* / P15208* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSGALG0000004075825
IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*ENSGALG0000004065125
DDR1 / Q03146* / Q08345* / discoidin domain receptor tyrosine kinase 1* / Epithelial discoidin domain-containing receptor 1 *ENSGALG0000000861624
ROS1 / ROS proto-oncogene 1, receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS *ENSGALG0000001491324
DDR2 / discoidin domain receptor tyrosine kinase 2 / Q16832* / Q62371* / Discoidin domain-containing receptor 2 *ENSGALG0000003932224
ROR1 / receptor tyrosine kinase like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSGALG0000001101923
ROR2 / receptor tyrosine kinase like orphan receptor 2 / Q01974* / Q9Z138*ENSGALG0000001520822
INSRR / insulin receptor related receptor / P14616* / Q9WTL4* / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain*ENSGALG0000001325322
LTK / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSGALG0000000861519
PTK7 / inactive tyrosine-protein kinase 7 precursor / Q8BKG3* / Q13308* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSGALG0000000860919
ALK* / P97793* / Q9UM73* / ALK receptor tyrosine kinase* / ALK tyrosine kinase receptor *ENSGALG0000000903414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001611  Leucine-rich repeat
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020455  Tyrosine-protein kinase, neurotrophic receptor, type 2
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020777  Tyrosine-protein kinase, neurotrophic receptor
 IPR031635  Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0007612 learning ISS
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0014047 glutamate secretion IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019222 regulation of metabolic process IEA
 biological_processGO:0021954 central nervous system neuron development ISS
 biological_processGO:0021987 cerebral cortex development ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0031547 brain-derived neurotrophic factor receptor signaling pathway ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0038179 neurotrophin signaling pathway IEA
 biological_processGO:0042490 mechanoreceptor differentiation IEA
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0046548 retinal rod cell development IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048668 collateral sprouting IMP
 biological_processGO:0048672 positive regulation of collateral sprouting IMP
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048935 peripheral nervous system neuron development IEA
 biological_processGO:0050772 positive regulation of axonogenesis ISS
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
 biological_processGO:1903859 regulation of dendrite extension IDA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005030 neurotrophin receptor activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043121 neurotrophin binding ISS
 molecular_functionGO:0048403 brain-derived neurotrophic factor binding ISS
 molecular_functionGO:0060175 brain-derived neurotrophic factor-activated receptor activity ISS


Pathways (from Reactome)
Pathway description
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000012594 NTRK2 / Q91987 / BDNF/NT-3 growth factors receptor / P15209* / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex
 ENSGALG00000012163 BDNF / P25429 / Brain-derived neurotrophic factor / P21237* / P23560*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr