ENSGALG00000039322


Gallus gallus

Features
Gene ID: ENSGALG00000039322
  
Biological name :DDR2
  
Synonyms : DDR2 / discoidin domain receptor tyrosine kinase 2
  
Possible biological names infered from orthology : Discoidin domain-containing receptor 2 / Q16832 / Q62371
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 3813929
Gene end: 3819587
  
Corresponding Affymetrix probe sets: Gga.1162.1.S1_at (Chicken Array)   GgaAffx.25591.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046395
Ensembl peptide - ENSGALP00000050290
NCBI entrez gene - 396404     See in Manteia.
RefSeq - XM_015290400
RefSeq - XM_015290401
RefSeq - XM_422211
swissprot - A0A1D5PC06
swissprot - A0A1D5P163
Ensembl - ENSGALG00000039322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddr2aENSDARG00000100693Danio rerio
 ddr2bENSDARG00000058695Danio rerio
 DDR2ENSG00000162733Homo sapiens
 Ddr2ENSMUSG00000026674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDR1 / Q03146* / Q08345* / discoidin domain receptor tyrosine kinase 1* / Epithelial discoidin domain-containing receptor 1 *ENSGALG0000000861649
NTRK2 / Q91987 / BDNF/NT-3 growth factors receptor / P15209* / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSGALG0000001259420
NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*ENSGALG0000004024120
INSRR / insulin receptor related receptor / P14616* / Q9WTL4* / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain*ENSGALG0000001325319
NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *ENSGALG0000001901919
IGF1R / insulin-like growth factor 1 receptor precursor / P08069* / insulin like growth factor 1 receptor*ENSGALG0000004065118
INSR / insulin receptor / P06213* / P15208* / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta*ENSGALG0000004075818
ROS1 / ROS proto-oncogene 1, receptor tyrosine kinase / P08922* / Q78DX7* / Proto-onco tyrosine-protein kinase ROS *ENSGALG0000001491318
MUSK / muscle, skeletal receptor tyrosine protein kinase precursor / O15146* / Q61006* / muscle associated receptor tyrosine kinase* / Muscle, skeletal receptor tyrosine-protein kinase *ENSGALG0000001572817
ROR1 / receptor tyrosine kinase like orphan receptor 1 / Q01973* / Q9Z139* / Inactive tyrosine-protein kinase transmembrane receptor ROR1 *ENSGALG0000001101915
ROR2 / receptor tyrosine kinase like orphan receptor 2 / Q01974* / Q9Z138*ENSGALG0000001520815
PTK7 / inactive tyrosine-protein kinase 7 precursor / Q8BKG3* / Q13308* / Inactive tyrosine-protein kinase 7 * / protein tyrosine kinase 7 (inactive)*ENSGALG0000000860914
LTK / leukocyte receptor tyrosine kinase / P08923* / P29376* / Leukocyte tyrosine kinase receptor *ENSGALG0000000861514
ALK* / P97793* / Q9UM73* / ALK receptor tyrosine kinase* / ALK tyrosine kinase receptor *ENSGALG0000000903411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029553  Epithelial discoidin domain-containing receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003416 endochondral bone growth IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0035988 chondrocyte proliferation IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0038062 protein tyrosine kinase collagen receptor activity IEA


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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