ENSMUSG00000026674


Mus musculus

Features
Gene ID: ENSMUSG00000026674
  
Biological name :Ddr2
  
Synonyms : Ddr2 / Discoidin domain-containing receptor 2 / Q62371
  
Possible biological names infered from orthology : discoidin domain receptor tyrosine kinase 2 / Q16832
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 169972307
Gene end: 170110762
  
Corresponding Affymetrix probe sets: 10359929 (MoGene1.0st)   1422738_at (Mouse Genome 430 2.0 Array)   1455688_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142191
Ensembl peptide - ENSMUSP00000027985
Ensembl peptide - ENSMUSP00000129624
Ensembl peptide - ENSMUSP00000141443
NCBI entrez gene - 18214     See in Manteia.
MGI - MGI:1345277
RefSeq - XM_006496697
RefSeq - XM_006496698
RefSeq - NM_022563
RefSeq - XM_006496696
RefSeq Peptide - NP_072075
swissprot - Q62371
swissprot - A0A0A6YXY2
Ensembl - ENSMUSG00000026674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddr2aENSDARG00000100693Danio rerio
 ddr2bENSDARG00000058695Danio rerio
 DDR2ENSGALG00000039322Gallus gallus
 DDR2ENSG00000162733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353455
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525425
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807224
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553423
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914623
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728022
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553322
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564022
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989321
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146418
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547118
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530518
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397217
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR034299  Discoidin domain-containing receptor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0003416 endochondral bone growth IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010763 positive regulation of fibroblast migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030500 regulation of bone mineralization ISO
 biological_processGO:0031214 biomineral tissue development IMP
 biological_processGO:0035988 chondrocyte proliferation IMP
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISS
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0005518 collagen binding ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0038062 protein tyrosine kinase collagen receptor activity ISO


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddr1tm1Wfv/Ddr1tm1Wfv,Ddr2tm1Kln/Ddr2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0000447 flattened snout 
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0001142 abnormal vaginal opening "a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

Allelic Composition: Ddr2tm1a(EUCOMM)Wtsi/Ddr2tm1a(EUCOMM)Wtsi
Genetic Background: FVB.B6N-Ddr2tm1a(EUCOMM)Wtsi

Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi
Genetic Background: FVB.B6N(Cg)-Ddr2tm1b(EUCOMM)Wtsi

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi
Genetic Background: FVB.B6N(Cg)-Ddr2tm1b(EUCOMM)Wtsi

Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6N * FVB/N

Allelic Composition: Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi,Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ddr2tm1a(EUCOMM)Wtsi/Ddr2tm1a(EUCOMM)Wtsi
Genetic Background: FVB.B6N-Ddr2tm1a(EUCOMM)Wtsi

Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi
Genetic Background: FVB.B6N(Cg)-Ddr2tm1b(EUCOMM)Wtsi

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olfr17tm3Mom/Olfr17+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2slie/Ddr2slie
Genetic Background: BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi
Genetic Background: FVB.B6N(Cg)-Ddr2tm1b(EUCOMM)Wtsi

Allelic Composition: Ddr2tm1b(EUCOMM)Wtsi/Ddr2tm1b(EUCOMM)Wtsi,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6N * FVB/N

Allelic Composition: Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi,Tg(MMTV-cre)#Mam/0,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6N * FVB * FVB/N

Allelic Composition: Ddr2tm1c(EUCOMM)Wtsi/Ddr2tm1c(EUCOMM)Wtsi,Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Ddr2tm1.1(cre/Esr1*)Rcow/Ddr2tm1.1(cre/Esr1*)Rcow
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
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Allelic Composition: Ddr2m1Anu/Ddr2m1Anu
Genetic Background: either: C57BL/6JSfdAnu-Ddr2m1Anu or (involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd * NOD/ShiLt)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026674 Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*  / complex






 

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