ENSMUSG00000005640


Mus musculus

Features
Gene ID: ENSMUSG00000005640
  
Biological name :Insrr
  
Synonyms : Insrr / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / Q9WTL4
  
Possible biological names infered from orthology : insulin receptor related receptor / P14616
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 87796951
Gene end: 87816101
  
Corresponding Affymetrix probe sets: 10493052 (MoGene1.0st)   1420564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029711
Ensembl peptide - ENSMUSP00000103208
NCBI entrez gene - 23920     See in Manteia.
MGI - MGI:1346037
RefSeq - XM_006501452
RefSeq - NM_011832
RefSeq - XM_006501451
RefSeq Peptide - NP_035962
swissprot - Q9WTL4
Ensembl - ENSMUSG00000005640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSRRENSGALG00000013253Gallus gallus
 INSRRENSG00000027644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553356
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553453
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989320
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547119
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914616
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728015
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807215
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525415
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353415
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729715
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667414
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530513
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397212
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028792  Insulin receptor-related protein
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030238 male sex determination IMP
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0071469 cellular response to alkaline pH ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha
Genetic Background: B6.129-Grip1tm1Rha

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T9J/T9J
Genetic Background: C57BL/6J-T9J

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insr+,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: T9J/T9J
Genetic Background: C57BL/6J-T9J

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insr+,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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