ENSG00000027644


Homo sapiens

Features
Gene ID: ENSG00000027644
  
Biological name :INSRR
  
Synonyms : INSRR / insulin receptor related receptor / P14616
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.1
Gene start: 156840063
Gene end: 156859018
  
Corresponding Affymetrix probe sets: 215776_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357178
NCBI entrez gene - 3645     See in Manteia.
OMIM - 147671
RefSeq - NM_014215
RefSeq Peptide - NP_055030
swissprot - P14616
Ensembl - ENSG00000027644
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSRRENSGALG00000013253Gallus gallus
 InsrrENSMUSG00000005640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044357
INSR / P06213 / insulin receptorENSG0000017110554
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793621
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109418
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053816
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840015
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805315
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030415
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458015
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252414
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273314
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907113
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265513
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028792  Insulin receptor-related protein
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030238 male sex determination IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0071469 cellular response to alkaline pH IDA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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