ENSG00000047936


Homo sapiens

Features
Gene ID: ENSG00000047936
  
Biological name :ROS1
  
Synonyms : P08922 / ROS1 / ROS proto-oncogene 1, receptor tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q22.1
Gene start: 117288300
Gene end: 117425855
  
Corresponding Affymetrix probe sets: 207569_at (Human Genome U133 Plus 2.0 Array)   244363_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357493
Ensembl peptide - ENSP00000357494
Ensembl peptide - ENSP00000384647
NCBI entrez gene - 6098     See in Manteia.
OMIM - 165020
RefSeq - XM_017011173
RefSeq - NM_002944
RefSeq - XM_011536055
RefSeq - XM_011536056
RefSeq - XM_011536057
RefSeq - XM_017011172
RefSeq - XM_006715548
RefSeq - XM_011536049
RefSeq - XM_011536050
RefSeq - XM_011536051
RefSeq - XM_011536052
RefSeq - XM_011536053
RefSeq - XM_011536054
RefSeq Peptide - NP_002935
swissprot - P08922
swissprot - Q5H8Y1
swissprot - H0Y3T9
Ensembl - ENSG00000047936
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ros1ENSDARG00000087197Danio rerio
 ROS1ENSGALG00000014913Gallus gallus
 Ros1ENSMUSG00000019893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INSRR / P14616 / insulin receptor related receptorENSG0000002764412
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265512
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044312
INSR / P06213 / insulin receptorENSG0000017110512
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109411
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG000000625249
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG000001984008
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG000000303048
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG000001480538
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG000001627338
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG000001405388
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG000002045808
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG000001690717
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG000001854837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IDA
 biological_processGO:0002066 columnar/cuboidal epithelial cell development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010966 regulation of phosphate transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032006 regulation of TOR signaling IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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