ENSMUSG00000019893


Mus musculus

Features
Gene ID: ENSMUSG00000019893
  
Biological name :Ros1
  
Synonyms : Proto-onco tyrosine-protein kinase ROS / Q78DX7 / Ros1
  
Possible biological names infered from orthology : P08922 / ROS proto-oncogene 1, receptor tyrosine kinase
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B3
Gene start: 52045721
Gene end: 52195244
  
Corresponding Affymetrix probe sets: 10369040 (MoGene1.0st)   1425970_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151720
Ensembl peptide - ENSMUSP00000151932
Ensembl peptide - ENSMUSP00000020045
Ensembl peptide - ENSMUSP00000151615
NCBI entrez gene - 19886     See in Manteia.
MGI - MGI:97999
RefSeq - XM_017313859
RefSeq - XM_011243147
RefSeq - XM_017313855
RefSeq - XM_017313856
RefSeq - XM_017313857
RefSeq - XM_017313858
RefSeq - NM_011282
RefSeq Peptide - NP_035412
swissprot - A0A1W2P858
swissprot - A0A1W2P7L6
swissprot - A0A1W2P7C6
swissprot - Q78DX7
Ensembl - ENSMUSG00000019893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ros1ENSDARG00000087197Danio rerio
 ROS1ENSGALG00000014913Gallus gallus
 ROS1ENSG00000047936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553312
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397212
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553412
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547111
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564011
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG000000272979
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG000000591468
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG000000035348
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG000000572808
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG000000552548
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG000000266748
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG000000214647
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG000000280727
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG000000353057


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0002066 columnar/cuboidal epithelial cell development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010966 regulation of phosphate transport IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IDA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ros1tm1Cbm/Ros1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002660 abnormal caput "anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ros1tm1Cbm/Ros1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ros1tm1Cbm/Ros1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ros1tm1Cbm/Ros1tm1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0009248 small caput "decrease in the average size of the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ros1tm2Cbm/Ros1tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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