ENSMUSG00000059146


Mus musculus

Features
Gene ID: ENSMUSG00000059146
  
Biological name :Ntrk3
  
Synonyms : NT-3 growth factor receptor / Ntrk3 / Q6VNS1
  
Possible biological names infered from orthology : neurotrophic receptor tyrosine kinase 3 / Q16288
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 78175959
Gene end: 78738012
  
Corresponding Affymetrix probe sets: 10564667 (MoGene1.0st)   1422329_a_at (Mouse Genome 430 2.0 Array)   1425070_at (Mouse Genome 430 2.0 Array)   1425071_s_at (Mouse Genome 430 2.0 Array)   1426003_at (Mouse Genome 430 2.0 Array)   1433825_at (Mouse Genome 430 2.0 Array)   1441491_at (Mouse Genome 430 2.0 Array)   1443970_at (Mouse Genome 430 2.0 Array)   1446622_at (Mouse Genome 430 2.0 Array)   1447723_at (Mouse Genome 430 2.0 Array)   1455917_at (Mouse Genome 430 2.0 Array)   1458707_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038324
Ensembl peptide - ENSMUSP00000146188
Ensembl peptide - ENSMUSP00000145958
Ensembl peptide - ENSMUSP00000145774
Ensembl peptide - ENSMUSP00000145689
Ensembl peptide - ENSMUSP00000145681
Ensembl peptide - ENSMUSP00000141599
Ensembl peptide - ENSMUSP00000141534
Ensembl peptide - ENSMUSP00000037909
NCBI entrez gene - 18213     See in Manteia.
MGI - MGI:97385
RefSeq - XM_017322023
RefSeq - NM_008746
RefSeq - NM_182809
RefSeq - XM_006540691
RefSeq - XM_006540692
RefSeq - XM_011250816
RefSeq - XM_011250817
RefSeq Peptide - NP_032772
RefSeq Peptide - NP_877961
swissprot - A0A0U1RP04
swissprot - A0A0U1RNS9
swissprot - A0A0U1RNS2
swissprot - A0A0A6YWL7
swissprot - A0A0A6YWF9
swissprot - Q6VNS1
swissprot - A0A0U1RPF1
swissprot - A0A0U1RPZ9
Ensembl - ENSMUSG00000059146
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntrk3aENSDARG00000077228Danio rerio
 ntrk3bENSDARG00000086214Danio rerio
 NTRK3ENSGALG00000040241Gallus gallus
 NTRK3ENSG00000140538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525454
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807247
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728027
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564025
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553325
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353424
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553424
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989324
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667424
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547122
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146421
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530521
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397220
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001611  Leucine-rich repeat
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020446  Tyrosine-protein kinase, neurotrophic receptor, type 3
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020777  Tyrosine-protein kinase, neurotrophic receptor
 IPR031635  Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019056 modulation by virus of host transcription IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0038179 neurotrophin signaling pathway IEA
 biological_processGO:0042490 mechanoreceptor differentiation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048691 positive regulation of axon extension involved in regeneration IGI
 biological_processGO:0048712 negative regulation of astrocyte differentiation IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis ISO
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070306 lens fiber cell differentiation IGI
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005030 neurotrophin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases
NTF3 activates NTRK3 signaling
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001024 small L5 ganglion "reduced size of L5 ganglion" [J:17792]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001527 athetotic walking movements "characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004746 abnormal cochlear IHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006404 abnormal lumbar dorsal root ganglion morphology "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm1.1Ohl/Esr1tm1.1Ohl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008467 absent proprioceptive neurons "absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ntrk3tm1Par/Ntrk3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mir155tm1.1Rsky/Mir155tm1.1Rsky
Genetic Background: B6.Cg-Mir155tm1Rsky/J

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / complex
 ENSMUSG00000013236 Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*  / reaction / complex
 ENSMUSG00000059146 Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction






 

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