ENSMUSG00000049107


Mus musculus

Features
Gene ID: ENSMUSG00000049107
  
Biological name :Ntf3
  
Synonyms : Neurotrophin-3 / Ntf3 / P20181
  
Possible biological names infered from orthology : P20783
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 126101412
Gene end: 126166910
  
Corresponding Affymetrix probe sets: 10548038 (MoGene1.0st)   1434802_s_at (Mouse Genome 430 2.0 Array)   1450803_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052302
Ensembl peptide - ENSMUSP00000107863
Ensembl peptide - ENSMUSP00000144828
NCBI entrez gene - 18205     See in Manteia.
MGI - MGI:97380
RefSeq - XM_006505716
RefSeq - NM_001164034
RefSeq - NM_001164035
RefSeq - NM_008742
RefSeq - XM_006505715
RefSeq Peptide - NP_032768
RefSeq Peptide - NP_001157506
RefSeq Peptide - NP_001157507
swissprot - P20181
swissprot - Q3V1A4
Ensembl - ENSMUSG00000049107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntf3ENSDARG00000059043Danio rerio
 NTF3ENSGALG00000027299Gallus gallus
 NTF3ENSG00000185652Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*ENSMUSG0000002785936
Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*ENSMUSG0000004848235
Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*ENSMUSG0000007412131


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR015578  Neurotrophin-3
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0002092 positive regulation of receptor internalization ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007274 neuromuscular synaptic transmission IDA
 biological_processGO:0007403 glial cell fate determination IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021675 nerve development IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0042490 mechanoreceptor differentiation IGI
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0043523 regulation of neuron apoptotic process IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048699 generation of neurons IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis ISO
 biological_processGO:0051145 smooth muscle cell differentiation IMP
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005165 neurotrophin receptor binding IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding TAS
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0042056 chemoattractant activity ISO


Pathways (from Reactome)
Pathway description
NTF3 activates NTRK3 signaling
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000778 abnormal tract 
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax6Sey/Pax6Sey-H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/10

 MP:0000907 small mesencephalic trigeminal nucleus "reduced size of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000960 abnormal sensory ganglia morphology "malformation or absence of a group of sensory neuron cell bodies" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae,Tg(Myog-Ntf3)5160Wds/0
Genetic Background: involves: C57BL/6 * CBA * CF-1

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm2Jae/Ntf3tm2Jae,Tg(PLAT-cre)116Sdu/0
Genetic Background: involves: 129S1/Sv

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ntf3tm1Mpin/Ntf3tm1Mpin
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Mpin/Ntf3+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

 MP:0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology "malformed receptors that respond to mechanical pressure or distortion in the skin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntf3tm1Mpin/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0000985 abnormal Merkel s receptor morphology "structural anomaly of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntf3tm1Mpin/Ntf3tm1Mpin
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Mpin/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0001000 absent golgi tendon organ "missing sensory organ in muscle that is involved in regulating muscle tension" [Principles of Neural Science:ISBN 0-8385-8034-3, J:23882]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001017 abnormal stellate ganglion morphology "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001021 small L4 ganglion "reduced size of L4 ganglion" [J:17792]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001024 small L5 ganglion "reduced size of L5 ganglion" [J:17792]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Mpin/Ntf3tm1Mpin
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
Genetic Background: B6.129S2-Ntf3tm1.1Eafx

Allelic Composition: Ntf3tm1Par/Ntf3tm2Jae,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
Genetic Background: B6.129S2-Ntf3tm1.1Eafx

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
Genetic Background: B6.129S2-Ntf3tm1.1Eafx

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
Genetic Background: B6.129S2-Ntf3tm1.1Eafx

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001527 athetotic walking movements "characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ntf3tm1.1Eafx/Ntf3tm1.1Eafx
Genetic Background: B6.129S2-Ntf3tm1.1Eafx

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm
Genetic Background: involves: 129S1/Sv

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr3tm1(cre)Mod/Egr3tm1(cre)Mod,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Ntf3tm2Jae/Ntf3tm2Jae
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0002976 vascular smooth muscle hypotrophy "decrease in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0003228 abnormal sinus venosus "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Ntf3tm1Par/Ntf3tm2Jae,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae,Tg(Myog-Ntf3)5160Wds/0
Genetic Background: involves: C57BL/6 * CBA * CF-1

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae,Tg(Myog-Ntf3)5160Wds/0
Genetic Background: involves: C57BL/6 * CBA * CF-1

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm2.1Jae/Ntf3tm2Jae,Olig2tm2(cre)Htak/Olig2+
Genetic Background: Not Specified

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0008467 absent proprioceptive neurons "absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010405 ostium secundum atrial septal defect "large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010440 anomalous pulmonary venous connection "abnormal development and attachment of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in either partial or complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery" [http://emedicine.medscape.com]
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Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0010449 heart right ventricle outflow tract stenosis "abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0010501 atrium myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the atrial part of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010557 dilated pulmonary artery "the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010558 sinus venosus hypoplasia "underdevelopment or reduced size of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0010576 premature closure of the ductus arteriosus "premature regression of the ductus arteriosus that normally regresses into a fibrous cord, the ligamentum arteriousum after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010578 abnormal heart left ventricle size "anomaly of the average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010581 abnormal atrium myocardial trabeculae morphology "any structural anomaly of the supporting bundles of muscular fibers lining the walls of the atria" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010605 thick pulmonary valve cusps "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3+
Genetic Background: involves: 129S1/Sv

 MP:0010617 thick mitral valve cusps 
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nrgntm1Kph/Nrgn+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae,Tg(Myog-Ntf3)5160Wds/0
Genetic Background: involves: C57BL/6 * CBA * CF-1

Allelic Composition: Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntf3tm1Mpin/Ntf3tm1Mpin
Genetic Background: involves: 129S1/Sv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3+
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf3tm1Jae/Ntf3tm1Jae
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntf3tm1Mpin/Ntf3tm1Mpin
Genetic Background: involves: 129S1/Sv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018697 Aatf / Q9JKX4 / apoptosis antagonizing transcription factor / Q9NY61*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex
 ENSMUSG00000059146 Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex / reaction
 ENSMUSG00000025151 Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*  / reaction / complex
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / reaction / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction






 

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