ENSMUSG00000027859


Mus musculus

Features
Gene ID: ENSMUSG00000027859
  
Biological name :Ngf
  
Synonyms : Beta-nerve growth factor / Ngf / P01139
  
Possible biological names infered from orthology : nerve growth factor / P01138
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 102469919
Gene end: 102521013
  
Corresponding Affymetrix probe sets: 10494817 (MoGene1.0st)   1419675_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142801
Ensembl peptide - ENSMUSP00000143428
Ensembl peptide - ENSMUSP00000040345
Ensembl peptide - ENSMUSP00000102538
NCBI entrez gene - 18049     See in Manteia.
MGI - MGI:97321
RefSeq - NM_013609
RefSeq - XM_006501108
RefSeq - NM_001112698
RefSeq Peptide - NP_001106168
RefSeq Peptide - NP_038637
swissprot - A0A0G2JEK0
swissprot - P01139
swissprot - Q6LDU8
swissprot - A0A0G2JG51
Ensembl - ENSMUSG00000027859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfaENSDARG00000058961Danio rerio
 ngfbENSDARG00000014050Danio rerio
 NGFENSGALG00000002556Gallus gallus
 NGFENSG00000134259Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntf3 / P20181 / Neurotrophin-3 / P20783*ENSMUSG0000004910732
Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*ENSMUSG0000004848228
Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*ENSMUSG0000007412124


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020425  Nerve growth factor, beta subunit
 IPR020437  Nerve growth factor, beta subunit, mammalian
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IGI
 biological_processGO:0014042 positive regulation of neuron maturation IGI
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation ISO
 biological_processGO:0038180 nerve growth factor signaling pathway IGI
 biological_processGO:0043388 positive regulation of DNA binding IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0045664 regulation of neuron differentiation IDA
 biological_processGO:0045773 positive regulation of axon extension IMP
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IDA
 biological_processGO:0046928 regulation of neurotransmitter secretion IGI
 biological_processGO:0048666 neuron development IDA
 biological_processGO:0048672 positive regulation of collateral sprouting IDA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IGI
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway ISO
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 cellular_componentGO:0044306 neuron projection terminus IDA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005163 nerve growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity IDA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
NGF processing
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
PI3K/AKT activation
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ntrk1tm1Apat/Ntrk1tm1Apat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ngftm1Gne/Ngftm1Gne
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001014 absent superior cervical ganglion "missing group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17792]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Myogtm2Whk/Myogtm2Whk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ngftm1.1Blhe/Ngf+,Sort1tm1Tew/Sort1tm1Tew
Genetic Background: B6.Cg-Ngftm1.1Blhe Sort1tm1Tew

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ngftm1.1Blhe/Ngf+,Sort1tm1Tew/Sort1tm1Tew
Genetic Background: B6.Cg-Ngftm1.1Blhe Sort1tm1Tew

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Ngftm1.1Blhe/Ngf+,Sort1tm1Tew/Sort1tm1Tew
Genetic Background: B6.Cg-Ngftm1.1Blhe Sort1tm1Tew

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Ngftm1Gne/Ngftm1Gne
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk11tm1Jsca/Mapk11+,Mapk14tm2Nbr/Mapk14tm2Nbr,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006408 dorsal root ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ngftm1Gne/Ngf+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pitx2tm1Jfm/Pitx2+
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / complex / reaction
 ENSMUSG00000003458 Ncstn / P57716 / Nicastrin / Q92542*  / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000018697 Aatf / Q9JKX4 / apoptosis antagonizing transcription factor / Q9NY61*  / complex / reaction
 ENSMUSG00000015750 Aph1a / Q8BVF7 / Gamma-secretase subunit APH-1A / Q96BI3* / aph-1 homolog A, gamma-secretase subunit*  / reaction
 ENSMUSG00000010609 Psen2 / presenilin 2 / P49810*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000015837 Q64337 / Sqstm1 / Sequestosome-1 / Q13501*  / reaction / complex
 ENSMUSG00000022420 Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*  / reaction
 ENSMUSG00000024713 Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*  / reaction
 ENSMUSG00000032375 Aph1b / Q8C7N7 / Gamma-secretase subunit APH-1B / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000019969 Psen1 / P49769 / presenilin 1 / P49768*  / reaction
 ENSMUSG00000036835 Psenen / Q9CQR7 / Gamma-secretase subunit PEN-2 / Q9NZ42* / AD000671.1* / presenilin enhancer gamma-secretase subunit*  / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex
 ENSMUSG00000028549 Q9CQ82 / Itgb3bp / integrin beta 3 binding protein (beta3-endonexin) / Q13352* / integrin subunit beta 3 binding protein*  / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000025132 Q99PT1 / Arhgdia / Rho GDP-dissociation inhibitor 1 / P52565* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000025151 Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*  / reaction / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction / complex
 ENSMUSG00000037643 Prkci / Q62074 / protein kinase C, iota / P41743*  / reaction / complex
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / reaction / complex
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / complex / reaction
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000046432 Bex3 / Q9WTZ9 / Protein BEX3 / Q00994* / brain expressed X-linked 3*  / reaction / complex
 ENSMUSG00000030513 Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*  / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / complex / reaction
 ENSMUSG00000053040 Aph1c / Q9DCZ9 / Putative gamma-secretase subunit APH-1C / APH1B* / Q8WW43* / aph-1 homolog B, gamma-secretase subunit*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr