| MP:0000025 | otic hypertelorism | "greater than normal space between the outer ears" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000102 | abnormal nasal bone morphology | "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000441 | wide skull | |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000704 | abnormal thymus development | "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000854 | abnormal cerebellum development | "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000857 | abnormal cerebellar foliation | "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0000890 | thin cerebellar molecular layer | "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854] |
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Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0001081 | abnormal cranial ganglia morphology | "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0001092 | abnormal trigeminal ganglion morphology | "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0001096 | abnormal glossopharyngeal ganglion morphology | "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0001100 | abnormal vagus ganglion morphology | "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Allelic Composition: Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0001300 | ocular hypertelorism | "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0001711 | abnormal placenta | |
Show
Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0002026 | leukemia | "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542] |
Show
Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0002759 | abnormal caudal vertebrae morphology | "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849] |
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Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0002762 | ectopic granule cells | "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0003421 | abnormal thyroid gland development | "failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0003923 | abnormal left atrium morphology | "structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0004062 | dilated right atrium | "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0004113 | abnormal aortic arch morphology | "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0004380 | short frontal bone | "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0008284 | abnormal hippocampus pyramidal cell layer | |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0008439 | abnormal cortical plate morphology | "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0008525 | decreased skull height | "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0008572 | abnormal Purkinje cell dendrite morphology | "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0009969 | abnormal cerebral cortex pyramidal cell morphology | "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Crktm1Cur/Crktm1Cur,Crkltm1Cur/Crkltm1Cur,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0010465 | aberrant origin of the right subclavian artery | "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
Show
Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
Show
Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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| MP:0013573 | abnormal parathyroid gland development | "aberrant formation or incomplete differentiation of either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH), a hormone that regulates calcium and phosphorous metabolism; in mouse, the parathyroids develop with the thymus from two common parathyroid/thymus primordia originating from the third pharyngeal pouch endoderm; the third pharyngeal pouches are formed at E9.5-E10 and are patterned into dorsal/anterior parathyroid and ventral/posterior thymus domains; the third pouch endoderm proliferates to form bilateral parathyroid/thymus common primordia at E11-E11.5; each primordium separates into one parathyroid gland and one thymus lobe at E12.5-E13.5, which then migrate to their eventual adult locations by about E14.5; in the adult mouse, the parathyroids are located near or embedded within the thyroid gland, and the thymus is situated in the anterior chest cavity" [MGI:Anna, PMID:17382312] |
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)
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