ENSMUSG00000044147


Mus musculus

Features
Gene ID: ENSMUSG00000044147
  
Biological name :Arf6
  
Synonyms : ADP-ribosylation factor 6 / Arf6 / P62331
  
Possible biological names infered from orthology : P62330
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C2
Gene start: 69372150
Gene end: 69373783
  
Corresponding Affymetrix probe sets: 10396108 (MoGene1.0st)   1418822_a_at (Mouse Genome 430 2.0 Array)   1418823_at (Mouse Genome 430 2.0 Array)   1418824_at (Mouse Genome 430 2.0 Array)   1434312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055862
NCBI entrez gene - 11845     See in Manteia.
MGI - MGI:99435
RefSeq - NM_007481
RefSeq Peptide - NP_031507
swissprot - P62331
swissprot - Q3U0D7
Ensembl - ENSMUSG00000044147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arf6aENSDARG00000101626Danio rerio
 arf6bENSDARG00000052928Danio rerio
 ARF6ENSGALG00000026944Gallus gallus
 ARF6ENSG00000165527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arf1 / P84078 / ADP-ribosylation factor 1 ENSMUSG0000004807670
Arf2 / Q8BSL7 / ADP-ribosylation factor 2 ENSMUSG0000006242170
Arf3 / P61205 / ADP-ribosylation factor 3 / P61204*ENSMUSG0000005185369
Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*ENSMUSG0000002187766
Arf5 / P84084 / ADP-ribosylation factor 5 / P84085*ENSMUSG0000002044065
Q8BGX0 / Trim23 / E3 ubiquitin-protein ligase TRIM23 / P36406* / tripartite motif containing 23*ENSMUSG0000002171254
Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*ENSMUSG0000002494446
Arl3 / Q9WUL7 / ADP-ribosylation factor-like protein 3 / P36405* / ADP ribosylation factor like GTPase 3*ENSMUSG0000002503545
Arl14 / ADP ribosylation factor like GTPase 14 / Q8N4G2*ENSMUSG0000009820742
Arl11 / Q6P3A9 / ADP-ribosylation factor-like protein 11 / Q969Q4* / ADP ribosylation factor like GTPase 11*ENSMUSG0000004315741
Arl8b / Q9CQW2 / ADP-ribosylation factor-like protein 8B / Q9NVJ2* / ADP ribosylation factor like GTPase 8B*ENSMUSG0000003010535
Arl8a / Q8VEH3 / ADP-ribosylation factor-like protein 8A / Q96BM9* / ADP ribosylation factor like GTPase 8A*ENSMUSG0000002642634
Arl15 / Q8BGR6 / ADP-ribosylation factor-like protein 15 / Q9NXU5* / ADP ribosylation factor like GTPase 15*ENSMUSG0000004234833


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0015031 protein transport TAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0031529 ruffle organization ISO
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0033028 myeloid cell apoptotic process IMP
 biological_processGO:0034143 regulation of toll-like receptor 4 signaling pathway NAS
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0035020 regulation of Rac protein signal transduction IEA
 biological_processGO:0036010 protein localization to endosome IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051489 regulation of filopodium assembly IEA
 biological_processGO:0060998 regulation of dendritic spine development IMP
 biological_processGO:0090162 establishment of epithelial cell polarity IMP
 biological_processGO:0097178 ruffle assembly IEA
 biological_processGO:0097284 hepatocyte apoptotic process IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IDA
 biological_processGO:2000171 negative regulation of dendrite development IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane ISS
 cellular_componentGO:0090543 Flemming body ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
MET receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
Show

Allelic Composition: F9tm1Emg/Y
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000020740 Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex
 ENSMUSG00000034412 P58802 / Tbc1d10a / TBC1 domain family member 10A / Q9BXI6* / AC004997.1*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr