ENSMUSG00000034412


Mus musculus

Features
Gene ID: ENSMUSG00000034412
  
Biological name :Tbc1d10a
  
Synonyms : P58802 / Tbc1d10a / TBC1 domain family member 10A
  
Possible biological names infered from orthology : AC004997.1 / Q9BXI6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 4186789
Gene end: 4215505
  
Corresponding Affymetrix probe sets: 10373890 (MoGene1.0st)   1445667_at (Mouse Genome 430 2.0 Array)   1448587_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036861
Ensembl peptide - ENSMUSP00000136453
NCBI entrez gene - 103724     See in Manteia.
MGI - MGI:2144164
RefSeq - XM_006514441
RefSeq - NM_134023
RefSeq Peptide - NP_598784
swissprot - P58802
swissprot - Q5SPX8
Ensembl - ENSMUSG00000034412
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d10aaENSDARG00000102070Danio rerio
 tbc1d10abENSDARG00000060096Danio rerio
 ENSGALG00000007954Gallus gallus
 AC004997.1ENSG00000248751Homo sapiens
 Q9BXI6ENSG00000099992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BHL3 / Tbc1d10b / TBC1 domain family member 10B / Q4KMP7*ENSMUSG0000004249258
Q8C9V1 / Carabin / Tbc1d10c / Q8IV04* / TBC1 domain family member 10C*ENSMUSG0000004024740
Q80XC3 / Usp6nl / USP6 N-terminal like / Q92738*ENSMUSG0000003904625
Grtp1 / Q9D3N8 / Growth hormone-regulated TBC protein 1 / Q5TC63*ENSMUSG0000003851519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:0045862 positive regulation of proteolysis ISO
 biological_processGO:0090630 activation of GTPase activity IBA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity ISO
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010095 increased chromosomal stability "decrease in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stard13tm1a(KOMP)Wtsi/Stard13tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044147 Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*  / reaction / complex
 ENSMUSG00000028860 Sytl1 / synaptotagmin like 1 / Q8IYJ3*  / reaction / complex






 

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