ENSMUSG00000040247


Mus musculus

Features
Gene ID: ENSMUSG00000040247
  
Biological name :Tbc1d10c
  
Synonyms : Carabin / Q8C9V1 / Tbc1d10c
  
Possible biological names infered from orthology : Q8IV04 / TBC1 domain family member 10C
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4184358
Gene end: 4191047
  
Corresponding Affymetrix probe sets: 10464647 (MoGene1.0st)   1454850_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042660
NCBI entrez gene - 108995     See in Manteia.
MGI - MGI:1922072
RefSeq - XM_011248598
RefSeq - NM_178650
RefSeq - XM_006531626
RefSeq - XM_006531628
RefSeq Peptide - NP_848765
swissprot - Q8C9V1
Ensembl - ENSMUSG00000040247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d10cENSDARG00000037408Danio rerio
 Q8IV04ENSG00000175463Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BHL3 / Tbc1d10b / TBC1 domain family member 10B / Q4KMP7*ENSMUSG0000004249245
P58802 / Tbc1d10a / TBC1 domain family member 10A / Q9BXI6* / AC004997.1*ENSMUSG0000003441245
Q80XC3 / Usp6nl / USP6 N-terminal like / Q92738*ENSMUSG0000003904624
Grtp1 / Q9D3N8 / Growth hormone-regulated TBC protein 1 / Q5TC63*ENSMUSG0000003851523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0050869 negative regulation of B cell activation IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090630 activation of GTPase activity IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0031527 filopodium membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0017137 Rab GTPase binding IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6J

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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