ENSG00000099992


Homo sapiens

Features
Gene ID: ENSG00000099992
  
Biological name :TBC1D10A
  
Synonyms : Q9BXI6 / TBC1D10A / TBC1 domain family member 10A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.2
Gene start: 30291990
Gene end: 30327046
  
Corresponding Affymetrix probe sets: 1570035_at (Human Genome U133 Plus 2.0 Array)   226133_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000215790
Ensembl peptide - ENSP00000385050
Ensembl peptide - ENSP00000400620
Ensembl peptide - ENSP00000389994
Ensembl peptide - ENSP00000377484
Ensembl peptide - ENSP00000384996
NCBI entrez gene - 83874     See in Manteia.
OMIM - 610020
RefSeq - NM_031937
RefSeq - NM_001204240
RefSeq Peptide - NP_001191169
RefSeq Peptide - NP_114143
swissprot - B5MD46
swissprot - Q9BXI6
swissprot - F8W9Y7
swissprot - F8WCD1
swissprot - F8WDN6
Ensembl - ENSG00000099992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d10aaENSDARG00000102070Danio rerio
 tbc1d10abENSDARG00000060096Danio rerio
 ENSGALG00000007954Gallus gallus
 P58802ENSMUSG00000034412Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4KMP7 / TBC1D10B / TBC1 domain family member 10BENSG0000016922158
AC004997.1ENSG0000024875154
Q8IV04 / TBC1D10C / TBC1 domain family member 10CENSG0000017546340
Q92738 / USP6NL / USP6 N-terminal likeENSG0000014842924
TBC1D3I / A0A087WXS9 / TBC1 domain family member 3IENSG0000027493318
Q6DHY5 / TBC1D3G / TBC1 domain family member 3GENSG0000026028718
P0C7X1 / TBC1D3H / TBC1 domain family member 3HENSG0000027422618
Q8IZP1 / TBC1D3 / TBC1 domain family member 3ENSG0000027461118
TBC1D3F / TBC1 domain family member 3FENSG0000027595418
B9A6J9 / TBC1D3L / TBC1 domain family member 3LENSG0000027451218
GRTP1 / Q5TC63 / growth hormone regulated TBC protein 1ENSG0000013983518
Q6IPX1 / TBC1D3C / TBC1 domain family member 3CENSG0000027829918
TBC1D3E / A0A087X179 / TBC1 domain family member 3EENSG0000027859918
TBC1D3D / A0A087WVF3 / TBC1 domain family member 3DENSG0000027441918
A6NDS4 / TBC1D3B / TBC1 domain family member 3BENSG0000027480818
TBC1D3K / A0A087X1G2 / TBC1 domain family member 3KENSG0000027351318
Q86UD7 / TBC1D26 / TBC1 domain family member 26ENSG0000021494612
Q2M2D7 / TBC1D28 / TBC1 domain family member 28ENSG000001893759


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0090630 activation of GTPase activity IBA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IDA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus TAS
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IBA
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142765 SYTL1 / Q8IYJ3 / synaptotagmin like 1  / reaction / complex
 ENSG00000165527 ARF6 / P62330 / ADP ribosylation factor 6  / reaction / complex






 

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