ENSG00000165527


Homo sapiens

Features
Gene ID: ENSG00000165527
  
Biological name :ARF6
  
Synonyms : ADP ribosylation factor 6 / ARF6 / P62330
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q21.3
Gene start: 49893092
Gene end: 49897054
  
Corresponding Affymetrix probe sets: 203311_s_at (Human Genome U133 Plus 2.0 Array)   203312_x_at (Human Genome U133 Plus 2.0 Array)   224788_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000298316
NCBI entrez gene - 382     See in Manteia.
OMIM - 600464
RefSeq - NM_001663
RefSeq Peptide - NP_001654
swissprot - P62330
Ensembl - ENSG00000165527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arf6aENSDARG00000101626Danio rerio
 arf6bENSDARG00000052928Danio rerio
 ARF6ENSGALG00000026944Gallus gallus
 Arf6ENSMUSG00000044147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARF1 / P84077 / ADP ribosylation factor 1ENSG0000014376170
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428769
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405965
ARF4 / P18085 / ADP ribosylation factor 4ENSG0000016837465
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359554
AC073610.3ENSG0000027282253
ARL2 / P36404 / ADP ribosylation factor like GTPase 2ENSG0000021346545
ARL3 / P36405 / ADP ribosylation factor like GTPase 3ENSG0000013817545
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221342
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967442
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410835
ARL8A / Q96BM9 / ADP ribosylation factor like GTPase 8AENSG0000014386234
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530533
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300330


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0032456 endocytic recycling IDA
 biological_processGO:0033028 myeloid cell apoptotic process IEA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0035020 regulation of Rac protein signal transduction IDA
 biological_processGO:0036010 protein localization to endosome IMP
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051489 regulation of filopodium assembly IDA
 biological_processGO:0060998 regulation of dendritic spine development IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IEA
 biological_processGO:0097178 ruffle assembly IDA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:2000009 negative regulation of protein localization to cell surface IEA
 biological_processGO:2000171 negative regulation of dendrite development IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
Clathrin-mediated endocytosis
MET receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000101199 Q8N6T3 / ARFGAP1 / ADP ribosylation factor GTPase activating protein 1  / complex
 ENSG00000099992 Q9BXI6 / TBC1D10A / TBC1 domain family member 10A  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr