ENSG00000138175


Homo sapiens

Features
Gene ID: ENSG00000138175
  
Biological name :ARL3
  
Synonyms : ADP ribosylation factor like GTPase 3 / ARL3 / P36405
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 102673731
Gene end: 102714407
  
Corresponding Affymetrix probe sets: 1568590_at (Human Genome U133 Plus 2.0 Array)   202641_at (Human Genome U133 Plus 2.0 Array)   213433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260746
NCBI entrez gene - 403     See in Manteia.
OMIM - 604695
RefSeq - NM_004311
RefSeq - XM_017016260
RefSeq Peptide - NP_004302
swissprot - P36405
Ensembl - ENSG00000138175
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl3ENSDARG00000071409Danio rerio
 zgc:110197ENSDARG00000056794Danio rerio
 ARL3ENSGALG00000008049Gallus gallus
 Arl3ENSMUSG00000025035Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARL2 / P36404 / ADP ribosylation factor like GTPase 2ENSG0000021346553
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428745
ARF1 / P84077 / ADP ribosylation factor 1ENSG0000014376145
ARF6 / P62330 / ADP ribosylation factor 6ENSG0000016552743
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405942
ARF4 / P18085 / ADP ribosylation factor 4ENSG0000016837441
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967441
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359540
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300337
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221337
AC073610.3ENSG0000027282235
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530532
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410832
ARL8A / Q96BM9 / ADP ribosylation factor like GTPase 8AENSG0000014386231


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IMP
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006892 post-Golgi vesicle-mediated transport IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042073 intraciliary transport IEA
 biological_processGO:0042461 photoreceptor cell development IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of myristoylated proteins to the cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102218 RP2 / O75695 / RP2, ARL3 GTPase activating protein  / complex / reaction
 ENSG00000175970 A6NIH7 / UNC119B / unc-119 lipid binding chaperone B  / reaction / complex
 ENSG00000205795 CYS1 / Q717R9 / cystin 1  / complex / reaction
 ENSG00000113971 NPHP3 / Q7Z494 / nephrocystin 3  / complex / reaction






 

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