ENSG00000143862


Homo sapiens

Features
Gene ID: ENSG00000143862
  
Biological name :ARL8A
  
Synonyms : ADP ribosylation factor like GTPase 8A / ARL8A / Q96BM9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 202133404
Gene end: 202144743
  
Corresponding Affymetrix probe sets: 225347_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000272217
Ensembl peptide - ENSP00000485023
NCBI entrez gene - 127829     See in Manteia.
OMIM - 616597
RefSeq - NM_001256129
RefSeq - NM_138795
RefSeq Peptide - NP_001243058
RefSeq Peptide - NP_620150
swissprot - Q96BM9
swissprot - A0A024R977
swissprot - A0A087X2J2
Ensembl - ENSG00000143862
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl8aENSDARG00000078686Danio rerio
 ARL8AENSGALG00000000606Gallus gallus
 Arl8aENSMUSG00000026426Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410892
ARF6 / P62330 / ADP ribosylation factor 6ENSG0000016552732
ARL2 / P36404 / ADP ribosylation factor like GTPase 2ENSG0000021346532
ARF1 / P84077 / ADP ribosylation factor 1ENSG0000014376132
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428731
ARL3 / P36405 / ADP ribosylation factor like GTPase 3ENSG0000013817530
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221330
ARF4 / P18085 / ADP ribosylation factor 4ENSG0000016837430
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530528
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405928
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967427
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359527
AC073610.3ENSG0000027282225
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300320


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding ISS
 molecular_functionGO:0048487 beta-tubulin binding ISS


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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