ENSG00000143761


Homo sapiens

Features
Gene ID: ENSG00000143761
  
Biological name :ARF1
  
Synonyms : ADP ribosylation factor 1 / ARF1 / P84077
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.13
Gene start: 228082660
Gene end: 228099212
  
Corresponding Affymetrix probe sets: 200065_s_at (Human Genome U133 Plus 2.0 Array)   208750_s_at (Human Genome U133 Plus 2.0 Array)   232175_at (Human Genome U133 Plus 2.0 Array)   244504_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442980
Ensembl peptide - ENSP00000272102
Ensembl peptide - ENSP00000440005
NCBI entrez gene - 375     See in Manteia.
OMIM - 103180
RefSeq - XM_017001233
RefSeq - NM_001024226
RefSeq - NM_001024227
RefSeq - NM_001024228
RefSeq - NM_001658
RefSeq Peptide - NP_001019397
RefSeq Peptide - NP_001019398
RefSeq Peptide - NP_001019399
RefSeq Peptide - NP_001649
swissprot - P84077
swissprot - A0A024R3Q3
Ensembl - ENSG00000143761
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARF1ENSGALG00000005393Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428796
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405980
ARF4 / P18085 / ADP ribosylation factor 4ENSG0000016837479
AC073610.3ENSG0000027282273
ARF6 / P62330 / ADP ribosylation factor 6ENSG0000016552767
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359560
ARL2 / P36404 / ADP ribosylation factor like GTPase 2ENSG0000021346546
ARL3 / P36405 / ADP ribosylation factor like GTPase 3ENSG0000013817545
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967444
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221339
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530533
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410833
ARL8A / Q96BM9 / ADP ribosylation factor like GTPase 8AENSG0000014386233
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300331


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002090 regulation of receptor internalization ISS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006878 cellular copper ion homeostasis IMP
 biological_processGO:0006892 post-Golgi vesicle-mediated transport TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0034315 regulation of Arp2/3 complex-mediated actin nucleation ISS
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0060292 long term synaptic depression ISS
 biological_processGO:0097061 dendritic spine organization ISS
 biological_processGO:0098586 cellular response to virus IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IMP


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Nef Mediated CD4 Down-regulation
MHC class II antigen presentation
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction / complex
 ENSG00000116095 Q9HB20 / PLEKHA3 / pleckstrin homology domain containing A3  / reaction / complex
 ENSG00000106086 Q96JA3 / PLEKHA8 / pleckstrin homology domain containing A8  / reaction / complex
 ENSG00000108669 CYTH1 / Q15438 / cytohesin 1  / complex / reaction
 ENSG00000105443 CYTH2 / Q99418 / cytohesin 2  / reaction / complex
 ENSG00000008256 CYTH3 / O43739 / cytohesin 3  / complex / reaction
 ENSG00000100055 CYTH4 / Q9UIA0 / cytohesin 4  / reaction / complex
 ENSG00000100815 Q15643 / TRIP11 / thyroid hormone receptor interactor 11  / complex / reaction
 ENSG00000143393 PI4KB / Q9UBF8 / phosphatidylinositol 4-kinase beta  / complex / reaction
 ENSG00000107862 GBF1 / Q92538 / golgi brefeldin A resistant guanine nucleotide exchange factor 1  / reaction






 

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