ENSG00000008256


Homo sapiens

Features
Gene ID: ENSG00000008256
  
Biological name :CYTH3
  
Synonyms : CYTH3 / cytohesin 3 / O43739
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.1
Gene start: 6161776
Gene end: 6272644
  
Corresponding Affymetrix probe sets: 206523_at (Human Genome U133 Plus 2.0 Array)   225147_at (Human Genome U133 Plus 2.0 Array)   236136_at (Human Genome U133 Plus 2.0 Array)   243752_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379967
Ensembl peptide - ENSP00000297044
NCBI entrez gene - 9265     See in Manteia.
OMIM - 605081
RefSeq - NM_004227
RefSeq Peptide - NP_004218
swissprot - O43739
Ensembl - ENSG00000008256
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyth1aENSDARG00000005159Danio rerio
 cyth3aENSDARG00000007807Danio rerio
 si:ch211-189a21.1ENSDARG00000089829Danio rerio
 ENSGALG00000007149Gallus gallus
 Cyth3ENSMUSG00000018001Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYTH1 / Q15438 / cytohesin 1ENSG0000010866983
CYTH2 / Q99418 / cytohesin 2ENSG0000010544380
CYTH4 / Q9UIA0 / cytohesin 4ENSG0000010005571
Q9Y6D5 / ARFGEF2 / ADP ribosylation factor guanine nucleotide exchange factor 2ENSG0000012419841
Q9Y6D6 / ARFGEF1 / ADP ribosylation factor guanine nucleotide exchange factor 1ENSG0000006677740
IQSEC1 / Q6DN90 / IQ motif and Sec7 domain 1ENSG0000014471130
IQSEC3 / Q9UPP2 / IQ motif and Sec7 domain 3ENSG0000012064529
IQSEC2 / Q5JU85 / IQ motif and Sec7 domain 2ENSG0000012431328
AC008403.1ENSG0000026846516
FBXO8 / Q9NRD0 / F-box protein 8ENSG0000016411715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR023394  Sec7, C-terminal domain superfamily
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048193 Golgi vesicle transport IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090162 establishment of epithelial cell polarity ISS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143761 ARF1 / P84077 / ADP ribosylation factor 1  / complex / reaction






 

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