ENSG00000066777


Homo sapiens

Features
Gene ID: ENSG00000066777
  
Biological name :ARFGEF1
  
Synonyms : ADP ribosylation factor guanine nucleotide exchange factor 1 / ARFGEF1 / Q9Y6D6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q13.2
Gene start: 67173511
Gene end: 67343677
  
Corresponding Affymetrix probe sets: 202955_s_at (Human Genome U133 Plus 2.0 Array)   202956_at (Human Genome U133 Plus 2.0 Array)   216266_s_at (Human Genome U133 Plus 2.0 Array)   243220_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262215
Ensembl peptide - ENSP00000430891
Ensembl peptide - ENSP00000429560
Ensembl peptide - ENSP00000429002
Ensembl peptide - ENSP00000428429
NCBI entrez gene - 10565     See in Manteia.
OMIM - 604141
RefSeq - XM_011517442
RefSeq - NM_006421
RefSeq - XM_005251134
RefSeq - XM_005251135
RefSeq - XM_005251136
RefSeq Peptide - NP_006412
swissprot - Q9Y6D6
swissprot - E5RJN9
swissprot - E5RHL7
swissprot - A0A024R7X0
swissprot - E5RIF2
swissprot - E5RHZ1
Ensembl - ENSG00000066777
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arfgef1ENSDARG00000063474Danio rerio
 ARFGEF1ENSGALG00000034610Gallus gallus
 G3X9K3ENSMUSG00000067851Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y6D5 / ARFGEF2 / ADP ribosylation factor guanine nucleotide exchange factor 2ENSG0000012419874
IQSEC3 / Q9UPP2 / IQ motif and Sec7 domain 3ENSG0000012064512
IQSEC1 / Q6DN90 / IQ motif and Sec7 domain 1ENSG0000014471111
IQSEC2 / Q5JU85 / IQ motif and Sec7 domain 2ENSG0000012431310
CYTH3 / O43739 / cytohesin 3ENSG000000082569
CYTH1 / Q15438 / cytohesin 1ENSG000001086699
CYTH4 / Q9UIA0 / cytohesin 4ENSG000001000558
CYTH2 / Q99418 / cytohesin 2ENSG000001054438
FBXO8 / Q9NRD0 / F-box protein 8ENSG000001641174
AC008403.1ENSG000002684652


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR011989  Armadillo-like helical
 IPR015403  Sec7, C-terminal
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032629  Mon2, dimerisation and cyclophilin-binding domain
 IPR032691  Guanine nucleotide exchange factor, N-terminal
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0010256 endomembrane system organization IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090284 positive regulation of protein glycosylation in Golgi IMP
 biological_processGO:0090303 positive regulation of wound healing IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IMP
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030532 small nuclear ribonucleoprotein complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017022 myosin binding IPI
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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