ENSMUSG00000067851


Mus musculus

Features
Gene ID: ENSMUSG00000067851
  
Biological name :Arfgef1
  
Synonyms : Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / G3X9K3
  
Possible biological names infered from orthology : ADP ribosylation factor guanine nucleotide exchange factor 1 / Q9Y6D6
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A2
Gene start: 10137571
Gene end: 10232670
  
Corresponding Affymetrix probe sets: 10353064 (MoGene1.0st)   10338155 (MoGene1.0st)   10338460 (MoGene1.0st)   10338683 (MoGene1.0st)   10338880 (MoGene1.0st)   10340553 (MoGene1.0st)   10341081 (MoGene1.0st)   10341204 (MoGene1.0st)   10341873 (MoGene1.0st)   10342012 (MoGene1.0st)   10342430 (MoGene1.0st)   10343099 (MoGene1.0st)   10343350 (MoGene1.0st)   10343906 (MoGene1.0st)   10344072 (MoGene1.0st)   10344379 (MoGene1.0st)   10338121 (MoGene1.0st)   10338303 (MoGene1.0st)   10338621 (MoGene1.0st)   10338895 (MoGene1.0st)   10339145 (MoGene1.0st)   10339503 (MoGene1.0st)   10340339 (MoGene1.0st)   10340349 (MoGene1.0st)   10340565 (MoGene1.0st)   10341256 (MoGene1.0st)   10341318 (MoGene1.0st)   10341535 (MoGene1.0st)   10341602 (MoGene1.0st)   10341690 (MoGene1.0st)   10342090 (MoGene1.0st)   10342363 (MoGene1.0st)   10342558 (MoGene1.0st)   10342600 (MoGene1.0st)   10342689 (MoGene1.0st)   10342808 (MoGene1.0st)   10342977 (MoGene1.0st)   10343554 (MoGene1.0st)   10343642 (MoGene1.0st)   10343756 (MoGene1.0st)   10343982 (MoGene1.0st)   10344261 (MoGene1.0st)   1415711_at (Mouse Genome 430 2.0 Array)   1437104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085986
Ensembl peptide - ENSMUSP00000118805
NCBI entrez gene - 211673     See in Manteia.
MGI - MGI:2442988
RefSeq - NM_001102430
RefSeq Peptide - NP_001095900
swissprot - G3X9K3
swissprot - D3YYK9
Ensembl - ENSMUSG00000067851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arfgef1ENSDARG00000063474Danio rerio
 ARFGEF1ENSGALG00000034610Gallus gallus
 Q9Y6D6ENSG00000066777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2 / Q9Y6D5* / ADP ribosylation factor guanine nucleotide exchange factor 2*ENSMUSG0000007458274
Iqsec3 / Q3TES0 / IQ motif and SEC7 domain-containing protein 3 / Q9UPP2* / IQ motif and Sec7 domain 3*ENSMUSG0000004079712
Iqsec1 / Q8R0S2 / IQ motif and SEC7 domain-containing protein 1 / Q6DN90* / IQ motif and Sec7 domain 1*ENSMUSG0000003431211
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111510
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG000000180019
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG000000180089
Cyth1 / Q9QX11 / Cytohesin-1 / Q15438*ENSMUSG000000171329
Cyth2 / P63034 / Cytohesin-2 / Q99418*ENSMUSG000000032698
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG000000382064


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR011989  Armadillo-like helical
 IPR015403  Sec7, C-terminal
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032629  Mon2, dimerisation and cyclophilin-binding domain
 IPR032691  Guanine nucleotide exchange factor, N-terminal
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0010256 endomembrane system organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0090284 positive regulation of protein glycosylation in Golgi IEA
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030532 small nuclear ribonucleoprotein complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0002946 delayed axon outgrowth "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

 MP:0020069 decreased neocortex size "size reduction or truncation of the neocortex" [GOC:NV]
Show

Allelic Composition: Lifrtm1Imx/Lifr+
Genetic Background: B6;129S7-Lifrtm1Imx/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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