ENSMUSG00000017132


Mus musculus

Features
Gene ID: ENSMUSG00000017132
  
Biological name :Cyth1
  
Synonyms : Cyth1 / Cytohesin-1 / Q9QX11
  
Possible biological names infered from orthology : Q15438
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 118132019
Gene end: 118248592
  
Corresponding Affymetrix probe sets: 10393544 (MoGene1.0st)   1418183_a_at (Mouse Genome 430 2.0 Array)   1447786_at (Mouse Genome 430 2.0 Array)   1448997_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017276
Ensembl peptide - ENSMUSP00000101909
Ensembl peptide - ENSMUSP00000101912
Ensembl peptide - ENSMUSP00000114792
Ensembl peptide - ENSMUSP00000097756
NCBI entrez gene - 19157     See in Manteia.
MGI - MGI:1334257
RefSeq - XM_011248805
RefSeq - NM_001112699
RefSeq - NM_001112700
RefSeq - NM_011180
RefSeq - XM_006532518
RefSeq - XM_006532519
RefSeq - XM_011248803
RefSeq Peptide - NP_035310
RefSeq Peptide - NP_001106169
RefSeq Peptide - NP_001106170
swissprot - Q8K3E8
swissprot - Q9QX11
swissprot - A2A517
swissprot - Q3TZ02
swissprot - B1AQE4
Ensembl - ENSMUSG00000017132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyth1aENSDARG00000076742Danio rerio
 cyth1bENSDARG00000021488Danio rerio
 CYTH1ENSGALG00000007093Gallus gallus
 CYTH1ENSG00000108669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG0000001800182
Cyth2 / P63034 / Cytohesin-2 / Q99418*ENSMUSG0000000326981
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG0000001800868
G3X9K3 / Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / Q9Y6D6* / ADP ribosylation factor guanine nucleotide exchange factor 1*ENSMUSG0000006785140
A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2 / Q9Y6D5* / ADP ribosylation factor guanine nucleotide exchange factor 2*ENSMUSG0000007458239
Iqsec3 / Q3TES0 / IQ motif and SEC7 domain-containing protein 3 / Q9UPP2* / IQ motif and Sec7 domain 3*ENSMUSG0000004079730
Iqsec1 / Q8R0S2 / IQ motif and SEC7 domain-containing protein 1 / Q6DN90* / IQ motif and Sec7 domain 1*ENSMUSG0000003431230
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111527
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG0000003820615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR023394  Sec7, C-terminal domain superfamily
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090162 establishment of epithelial cell polarity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
Show

Allelic Composition: Ano6tm1Avor/Ano6tm1Avor
Genetic Background: involves: 129

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
Show

Allelic Composition: Ano6tm1Avor/Ano6tm1Avor
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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