ENSMUSG00000034312


Mus musculus

Features
Gene ID: ENSMUSG00000034312
  
Biological name :Iqsec1
  
Synonyms : IQ motif and SEC7 domain-containing protein 1 / Iqsec1 / Q8R0S2
  
Possible biological names infered from orthology : IQ motif and Sec7 domain 1 / Q6DN90
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 90656088
Gene end: 90988685
  
Corresponding Affymetrix probe sets: 10546272 (MoGene1.0st)   1427145_at (Mouse Genome 430 2.0 Array)   1452327_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118802
Ensembl peptide - ENSMUSP00000148669
Ensembl peptide - ENSMUSP00000098710
Ensembl peptide - ENSMUSP00000098712
NCBI entrez gene - 232227     See in Manteia.
MGI - MGI:1196356
RefSeq - XM_017321534
RefSeq - XM_006505991
RefSeq - XM_006505992
RefSeq - XM_011241301
RefSeq - XM_011241302
RefSeq - XM_017321532
RefSeq - XM_017321533
RefSeq - NM_001134383
RefSeq - NM_001134384
RefSeq - XM_006505983
RefSeq - XM_006505984
RefSeq - XM_006505985
RefSeq - XM_006505986
RefSeq - XM_006505987
RefSeq - XM_006505988
RefSeq - XM_006505990
RefSeq Peptide - NP_001127855
RefSeq Peptide - NP_001127856
swissprot - E9PUA3
swissprot - A0A1D5RM83
swissprot - Q8R0S2
swissprot - A0A0R4J1U6
Ensembl - ENSMUSG00000034312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqsec1bENSDARG00000016551Danio rerio
 LO017700.1ENSDARG00000073822Danio rerio
 IQSEC1ENSGALG00000005042Gallus gallus
 IQSEC1ENSG00000144711Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111559
Iqsec3 / Q3TES0 / IQ motif and SEC7 domain-containing protein 3 / Q9UPP2* / IQ motif and Sec7 domain 3*ENSMUSG0000004079739
G3X9K3 / Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / Q9Y6D6* / ADP ribosylation factor guanine nucleotide exchange factor 1*ENSMUSG0000006785119
A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2 / Q9Y6D5* / ADP ribosylation factor guanine nucleotide exchange factor 2*ENSMUSG0000007458219
Cyth2 / P63034 / Cytohesin-2 / Q99418*ENSMUSG0000000326911
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG0000001800111
Cyth1 / Q9QX11 / Cytohesin-1 / Q15438*ENSMUSG0000001713211
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG0000001800810
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG000000382068


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000904  Sec7 domain
 IPR011993  PH-like domain superfamily
 IPR023394  Sec7, C-terminal domain superfamily
 IPR030737  IQ motif and SEC7 domain-containing protein 1
 IPR033742  IQ motif and SEC7 domain-containing protein, PH domain
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a1ENU4004/Col4a1+
Genetic Background: C3.D2-Col4a1ENU4004

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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