ENSMUSG00000074582


Mus musculus

Features
Gene ID: ENSMUSG00000074582
  
Biological name :Arfgef2
  
Synonyms : A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2
  
Possible biological names infered from orthology : ADP ribosylation factor guanine nucleotide exchange factor 2 / Q9Y6D5
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 166805588
Gene end: 166898052
  
Corresponding Affymetrix probe sets: 10478754 (MoGene1.0st)   10478772 (MoGene1.0st)   10478774 (MoGene1.0st)   10478776 (MoGene1.0st)   10478778 (MoGene1.0st)   1436192_at (Mouse Genome 430 2.0 Array)   1443842_at (Mouse Genome 430 2.0 Array)   1454982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131572
Ensembl peptide - ENSMUSP00000096677
NCBI entrez gene - 99371     See in Manteia.
MGI - MGI:2139354
RefSeq - XM_006500483
RefSeq - XM_011239875
RefSeq - NM_001085495
RefSeq - XM_006500484
RefSeq Peptide - NP_001078964
swissprot - F6YCJ0
swissprot - A2A5R2
Ensembl - ENSMUSG00000074582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9Y6D5ENSG00000124198Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G3X9K3 / Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / Q9Y6D6* / ADP ribosylation factor guanine nucleotide exchange factor 1*ENSMUSG0000006785176
Iqsec1 / Q8R0S2 / IQ motif and SEC7 domain-containing protein 1 / Q6DN90* / IQ motif and Sec7 domain 1*ENSMUSG0000003431212
Iqsec3 / Q3TES0 / IQ motif and SEC7 domain-containing protein 3 / Q9UPP2* / IQ motif and Sec7 domain 3*ENSMUSG0000004079712
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111511
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG000000180089
Cyth1 / Q9QX11 / Cytohesin-1 / Q15438*ENSMUSG000000171329
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG000000180019
Cyth2 / P63034 / Cytohesin-2 / Q99418*ENSMUSG000000032698
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG000000382064


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR011989  Armadillo-like helical
 IPR015403  Sec7, C-terminal
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032629  Mon2, dimerisation and cyclophilin-binding domain
 IPR032691  Guanine nucleotide exchange factor, N-terminal
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001881 receptor recycling IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006893 Golgi to plasma membrane transport IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0010256 endomembrane system organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005879 axonemal microtubule IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0032279 asymmetric synapse IEA
 cellular_componentGO:0032280 symmetric synapse IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0050811 GABA receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0003257 abnormal abdominal wall "malformation in the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Wnt7apx-J/Wnt7apx-J
Genetic Background: C57BL/6J-Wnt7apx-J/GrsrJ

Allelic Composition: Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
Show

Allelic Composition: Arfgef2tm1Itl/Arfgef2tm1Itl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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