ENSMUSG00000003269


Mus musculus

Features
Gene ID: ENSMUSG00000003269
  
Biological name :Cyth2
  
Synonyms : Cyth2 / Cytohesin-2 / P63034
  
Possible biological names infered from orthology : Q99418
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45806637
Gene end: 45814581
  
Corresponding Affymetrix probe sets: 10563390 (MoGene1.0st)   1450103_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103357
Ensembl peptide - ENSMUSP00000152189
Ensembl peptide - ENSMUSP00000147723
Ensembl peptide - ENSMUSP00000147706
Ensembl peptide - ENSMUSP00000147587
Ensembl peptide - ENSMUSP00000147457
Ensembl peptide - ENSMUSP00000147451
Ensembl peptide - ENSMUSP00000147275
Ensembl peptide - ENSMUSP00000051423
NCBI entrez gene - 19158     See in Manteia.
MGI - MGI:1334255
RefSeq - NM_011181
RefSeq - NM_001112701
RefSeq Peptide - NP_001106171
RefSeq Peptide - NP_035311
swissprot - A0A1B0GRB2
swissprot - A0A1B0GQW2
swissprot - P63034
swissprot - A0A1Y7VIW9
swissprot - Q99KH2
swissprot - A0A1B0GRZ2
swissprot - A0A1B0GRX7
swissprot - A0A1B0GRM7
swissprot - A0A1B0GRB8
Ensembl - ENSMUSG00000003269
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYTH2ENSDARG00000028800Danio rerio
 CYTH2ENSG00000105443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyth1 / Q9QX11 / Cytohesin-1 / Q15438*ENSMUSG0000001713281
Cyth3 / O08967 / Cytohesin-3 / O43739*ENSMUSG0000001800179
Cyth4 / Q80YW0 / Cytohesin-4 / Q9UIA0*ENSMUSG0000001800867
G3X9K3 / Arfgef1 / Brefeldin A-inhibited guanine nucleotide-exchange protein 1 / Q9Y6D6* / ADP ribosylation factor guanine nucleotide exchange factor 1*ENSMUSG0000006785138
A2A5R2 / Arfgef2 / Brefeldin A-inhibited guanine nucleotide-exchange protein 2 / Q9Y6D5* / ADP ribosylation factor guanine nucleotide exchange factor 2*ENSMUSG0000007458237
Iqsec1 / Q8R0S2 / IQ motif and SEC7 domain-containing protein 1 / Q6DN90* / IQ motif and Sec7 domain 1*ENSMUSG0000003431231
Iqsec3 / Q3TES0 / IQ motif and SEC7 domain-containing protein 3 / Q9UPP2* / IQ motif and Sec7 domain 3*ENSMUSG0000004079729
Iqsec2 / IQ motif and Sec7 domain 2 / Q5JU85*ENSMUSG0000004111528
Fbxo8 / Q9QZN3 / F-box only protein 8 / Q9NRD0* / F-box protein 8*ENSMUSG0000003820616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR023394  Sec7, C-terminal domain superfamily
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030155 regulation of cell adhesion ISO
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Adora2btm1Msit/Adora2btm1Msit,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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