ENSG00000213465


Homo sapiens

Features
Gene ID: ENSG00000213465
  
Biological name :ARL2
  
Synonyms : ADP ribosylation factor like GTPase 2 / ARL2 / P36404
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 65014113
Gene end: 65022184
  
Corresponding Affymetrix probe sets: 202564_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246747
Ensembl peptide - ENSP00000432971
Ensembl peptide - ENSP00000436021
NCBI entrez gene - 402     See in Manteia.
OMIM - 601175
RefSeq - NM_001199745
RefSeq - NM_001667
RefSeq Peptide - NP_001186674
RefSeq Peptide - NP_001658
swissprot - P36404
swissprot - Q53YD8
Ensembl - ENSG00000213465
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl2ENSDARG00000069496Danio rerio
 Arl2ENSMUSG00000024944Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300361
ARL3 / P36405 / ADP ribosylation factor like GTPase 3ENSG0000013817553
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428746
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405946
ARF1 / P84077 / ADP ribosylation factor 1ENSG0000014376146
ARF4 / P18085 / ADP ribosylation factor 4ENSG0000016837444
ARF6 / P62330 / ADP ribosylation factor 6ENSG0000016552743
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359543
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967440
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221339
AC073610.3ENSG0000027282238
ARL8A / Q96BM9 / ADP ribosylation factor like GTPase 8AENSG0000014386232
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410832
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530530


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007021 tubulin complex assembly TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007098 centrosome cycle IMP
 biological_processGO:0010811 positive regulation of cell-substrate adhesion ISS
 biological_processGO:0031113 regulation of microtubule polymerization IMP
 biological_processGO:0031116 positive regulation of microtubule polymerization IDA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051457 maintenance of protein location in nucleus IDA
 biological_processGO:0070830 bicellular tight junction assembly ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016328 lateral plasma membrane ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IMP
 molecular_functionGO:0005095 GTPase inhibitor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IMP


Pathways (from Reactome)
Pathway description
Post-chaperonin tubulin folding pathway
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102931 ARL2BP / Q9Y2Y0 / ADP ribosylation factor like GTPase 2 binding protein  / reaction / complex
 ENSG00000151729 P12235 / SLC25A4 / solute carrier family 25 member 4  / complex / reaction






 

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