ENSG00000168374


Homo sapiens

Features
Gene ID: ENSG00000168374
  
Biological name :ARF4
  
Synonyms : ADP ribosylation factor 4 / ARF4 / P18085
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.3
Gene start: 57571363
Gene end: 57598220
  
Corresponding Affymetrix probe sets: 201096_s_at (Human Genome U133 Plus 2.0 Array)   201097_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417501
Ensembl peptide - ENSP00000475828
Ensembl peptide - ENSP00000420655
Ensembl peptide - ENSP00000420254
Ensembl peptide - ENSP00000418388
Ensembl peptide - ENSP00000306010
NCBI entrez gene - 378     See in Manteia.
OMIM - 601177
RefSeq - NM_001660
RefSeq Peptide - NP_001651
swissprot - F8WDB3
swissprot - P18085
swissprot - C9JPM4
swissprot - U3KQF2
swissprot - C9JAK5
swissprot - C9J6P1
Ensembl - ENSG00000168374
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARF4ENSGALG00000005622Gallus gallus
 Arf4ENSMUSG00000021877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARF5 / P84085 / ADP ribosylation factor 5ENSG0000000405989
ARF1 / P84077 / ADP ribosylation factor 1ENSG0000014376179
ARF3 / P61204 / ADP ribosylation factor 3ENSG0000013428778
ARF6 / P62330 / ADP ribosylation factor 6ENSG0000016552763
AC073610.3ENSG0000027282261
P36406 / TRIM23 / tripartite motif containing 23ENSG0000011359557
ARL2 / P36404 / ADP ribosylation factor like GTPase 2ENSG0000021346545
ARL14 / Q8N4G2 / ADP ribosylation factor like GTPase 14ENSG0000017967442
ARL3 / P36405 / ADP ribosylation factor like GTPase 3ENSG0000013817542
ARL11 / Q969Q4 / ADP ribosylation factor like GTPase 11ENSG0000015221338
ARL8B / Q9NVJ2 / ADP ribosylation factor like GTPase 8BENSG0000013410832
ARL15 / Q9NXU5 / ADP ribosylation factor like GTPase 15ENSG0000018530531
ARL8A / Q96BM9 / ADP ribosylation factor like GTPase 8AENSG0000014386231
ARL2-SNX15 / ARL2-SNX15 readthrough (NMD candidate)ENSG0000027300329


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IGI
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0031584 activation of phospholipase D activity IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045176 apical protein localization IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0060996 dendritic spine development IDA
 biological_processGO:0061512 protein localization to cilium IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129083 COPB1 / P53618 / coatomer protein complex subunit beta 1  / complex / reaction
 ENSG00000122218 COPA / P53621 / coatomer protein complex subunit alpha  / complex / reaction
 ENSG00000111481 COPZ1 / P61923 / coatomer protein complex subunit zeta 1  / complex / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000105669 COPE / O14579 / coatomer protein complex subunit epsilon  / complex / reaction
 ENSG00000095139 ARCN1 / P48444 / archain 1  / complex / reaction
 ENSG00000008710 PKD1 / P98161 / polycystin 1, transient receptor potential channel interacting  / complex / reaction
 ENSG00000183862 CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2  / reaction / complex
 ENSG00000090565 O75154 / RAB11FIP3 / RAB11 family interacting protein 3  / reaction / complex
 ENSG00000158623 COPG2 / Q9UBF2 / coatomer protein complex subunit gamma 2  / complex / reaction
 ENSG00000163914 RHO / P08100 / rhodopsin  / reaction / complex
 ENSG00000174903 RAB1B / Q9H0U4 / RAB1B, member RAS oncogene family  / complex / reaction
 ENSG00000107862 GBF1 / Q92538 / golgi brefeldin A resistant guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000181789 COPG1 / Q9Y678 / coatomer protein complex subunit gamma 1  / reaction / complex
 ENSG00000070729 CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1  / complex / reaction
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / reaction / complex
 ENSG00000184432 COPB2 / P35606 / coatomer protein complex subunit beta 2  / complex / reaction
 ENSG00000132259 CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4  / reaction / complex
 ENSG00000005243 COPZ2 / Q9P299 / coatomer protein complex subunit zeta 2  / reaction / complex
 ENSG00000153317 ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  / complex / reaction






 

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