ENSMUSG00000021877


Mus musculus

Features
Gene ID: ENSMUSG00000021877
  
Biological name :Arf4
  
Synonyms : ADP-ribosylation factor 4 / Arf4 / P61750
  
Possible biological names infered from orthology : P18085
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 26638074
Gene end: 26665084
  
Corresponding Affymetrix probe sets: 10413304 (MoGene1.0st)   1423052_at (Mouse Genome 430 2.0 Array)   1423053_at (Mouse Genome 430 2.0 Array)   1434074_x_at (Mouse Genome 430 2.0 Array)   1439367_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107937
Ensembl peptide - ENSMUSP00000132159
Ensembl peptide - ENSMUSP00000127272
Ensembl peptide - ENSMUSP00000022429
NCBI entrez gene - 11843     See in Manteia.
MGI - MGI:99433
RefSeq - NM_007479
RefSeq Peptide - NP_031505
swissprot - P61750
swissprot - E9Q798
swissprot - Q14BR4
swissprot - E9Q2C2
swissprot - F6UFB9
Ensembl - ENSMUSG00000021877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARF4ENSGALG00000005622Gallus gallus
 ARF4ENSG00000168374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arf5 / P84084 / ADP-ribosylation factor 5 / P84085*ENSMUSG0000002044090
Arf1 / P84078 / ADP-ribosylation factor 1 ENSMUSG0000004807681
Arf2 / Q8BSL7 / ADP-ribosylation factor 2 ENSMUSG0000006242181
Arf3 / P61205 / ADP-ribosylation factor 3 / P61204*ENSMUSG0000005185379
Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*ENSMUSG0000004414764
Q8BGX0 / Trim23 / E3 ubiquitin-protein ligase TRIM23 / P36406* / tripartite motif containing 23*ENSMUSG0000002171257
Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*ENSMUSG0000002494447
Arl3 / Q9WUL7 / ADP-ribosylation factor-like protein 3 / P36405* / ADP ribosylation factor like GTPase 3*ENSMUSG0000002503543
Arl14 / ADP ribosylation factor like GTPase 14 / Q8N4G2*ENSMUSG0000009820742
Arl11 / Q6P3A9 / ADP-ribosylation factor-like protein 11 / Q969Q4* / ADP ribosylation factor like GTPase 11*ENSMUSG0000004315739
Arl8b / Q9CQW2 / ADP-ribosylation factor-like protein 8B / Q9NVJ2* / ADP ribosylation factor like GTPase 8B*ENSMUSG0000003010532
Arl8a / Q8VEH3 / ADP-ribosylation factor-like protein 8A / Q96BM9* / ADP ribosylation factor like GTPase 8A*ENSMUSG0000002642629
Arl15 / Q8BGR6 / ADP-ribosylation factor-like protein 15 / Q9NXU5* / ADP ribosylation factor like GTPase 15*ENSMUSG0000004234829


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0061512 protein localization to cilium IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043197 dendritic spine IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex / reaction
 ENSMUSG00000026553 Copa / Q8CIE6 / Coatomer subunit alpha Xenin Proxenin / P53621* / coatomer protein complex subunit alpha*  / complex / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000032458 Copb2 / O55029 / Coatomer subunit beta / P35606* / coatomer protein complex subunit beta 2*  / reaction / complex
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / reaction / complex
 ENSMUSG00000018672 Copz2 / Q9JHH9 / Coatomer subunit zeta-2 / Q9P299* / coatomer protein complex subunit zeta 2*  / reaction / complex
 ENSMUSG00000030058 Copg1 / Q9QZE5 / Coatomer subunit gamma-1 / Q9Y678* / coatomer protein complex subunit gamma 1*  / reaction / complex
 ENSMUSG00000060992 Copz1 / P61924 / Coatomer subunit zeta-1 / P61923* / coatomer protein complex subunit zeta 1*  / complex / reaction
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / complex / reaction
 ENSMUSG00000024870 Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*  / complex / reaction
 ENSMUSG00000025607 Copg2 / Q9QXK3 / Coatomer subunit gamma-2 / Q9UBF2* / coatomer protein complex subunit gamma 2*  / complex / reaction
 ENSMUSG00000032096 Arcn1 / Q5XJY5 / Coatomer subunit delta / P48444* / archain 1*  / reaction / complex
 ENSMUSG00000030754 Copb1 / Q9JIF7 / Coatomer subunit beta / P53618* / coatomer protein complex subunit beta 1*  / complex / reaction
 ENSMUSG00000055681 Cope / O89079 / Coatomer subunit epsilon / O14579* / coatomer protein complex subunit epsilon*  / complex / reaction
 ENSMUSG00000030897 Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*  / reaction / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex / reaction
 ENSMUSG00000032855 Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*  / complex / reaction






 

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