ENSMUSG00000032096


Mus musculus

Features
Gene ID: ENSMUSG00000032096
  
Biological name :Arcn1
  
Synonyms : Arcn1 / Coatomer subunit delta / Q5XJY5
  
Possible biological names infered from orthology : archain 1 / P48444
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44741564
Gene end: 44767845
  
Corresponding Affymetrix probe sets: 10592919 (MoGene1.0st)   1423743_at (Mouse Genome 430 2.0 Array)   1436062_at (Mouse Genome 430 2.0 Array)   1451089_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034607
NCBI entrez gene - 213827     See in Manteia.
MGI - MGI:2387591
RefSeq - NM_145985
RefSeq Peptide - NP_666097
swissprot - Q5XJY5
Ensembl - ENSMUSG00000032096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arcn1aENSDARG00000002792Danio rerio
 arcn1bENSDARG00000031214Danio rerio
 ARCN1ENSGALG00000007430Gallus gallus
 ARCN1ENSG00000095139Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011012  Longin-like domain superfamily
 IPR022775  AP complex, mu/sigma subunit
 IPR027059  Coatomer delta subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0021691 cerebellar Purkinje cell layer maturation IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048193 Golgi vesicle transport IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030126 COPI vesicle coat IEA
 cellular_componentGO:0030137 COPI-coated vesicle IDA
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: LmnaDhe/Lmna+
Genetic Background: B6(D2)-LmnaDhe/TyGrsrJ

 MP:0003214 neurofibrillary tangles "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0008733 abnormal hair shaft melanin granule distribution "disruption in the regular arrangement of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0009992 abnormal cerebellum vermis lobule IX morphology 
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0009994 abnormal cerebellum vermis lobule VI morphology 
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0009995 abnormal cerebellum vermis lobule VII morphology 
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

 MP:0009997 abnormal cerebellum vermis lobule X morphology 
Show

Allelic Composition: Arcn1nur17/Arcn1nur17
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018672 Copz2 / Q9JHH9 / Coatomer subunit zeta-2 / Q9P299* / coatomer protein complex subunit zeta 2*  / complex
 ENSMUSG00000026553 Copa / Q8CIE6 / Coatomer subunit alpha Xenin Proxenin / P53621* / coatomer protein complex subunit alpha*  / complex
 ENSMUSG00000024870 Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*  / complex / reaction
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000030754 Copb1 / Q9JIF7 / Coatomer subunit beta / P53618* / coatomer protein complex subunit beta 1*  / complex
 ENSMUSG00000030058 Copg1 / Q9QZE5 / Coatomer subunit gamma-1 / Q9Y678* / coatomer protein complex subunit gamma 1*  / complex
 ENSMUSG00000025607 Copg2 / Q9QXK3 / Coatomer subunit gamma-2 / Q9UBF2* / coatomer protein complex subunit gamma 2*  / complex
 ENSMUSG00000055681 Cope / O89079 / Coatomer subunit epsilon / O14579* / coatomer protein complex subunit epsilon*  / complex
 ENSMUSG00000032458 Copb2 / O55029 / Coatomer subunit beta / P35606* / coatomer protein complex subunit beta 2*  / complex
 ENSMUSG00000060992 Copz1 / P61924 / Coatomer subunit zeta-1 / P61923* / coatomer protein complex subunit zeta 1*  / complex






 

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