ENSMUSG00000032458


Mus musculus

Features
Gene ID: ENSMUSG00000032458
  
Biological name :Copb2
  
Synonyms : Coatomer subunit beta / Copb2 / O55029
  
Possible biological names infered from orthology : coatomer protein complex subunit beta 2 / P35606
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 98563721
Gene end: 98588382
  
Corresponding Affymetrix probe sets: 10588049 (MoGene1.0st)   1452102_at (Mouse Genome 430 2.0 Array)   1456175_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035033
NCBI entrez gene - 50797     See in Manteia.
MGI - MGI:1354962
RefSeq - NM_015827
RefSeq Peptide - NP_056642
swissprot - O55029
Ensembl - ENSMUSG00000032458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 copb2ENSDARG00000038743Danio rerio
 COPB2ENSGALG00000005357Gallus gallus
 COPB2ENSG00000184432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006692  Coatomer, WD associated region
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016453  Coatomer beta" subunit (COPB2)
 IPR017986  WD40-repeat-containing domain
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IBA
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA
 biological_processGO:0006891 intra-Golgi vesicle-mediated transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030126 COPI vesicle coat IEA
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0009850 embryonic lethality between implantation and placentation "death anytime after implantation but before placentation (Mus: E4.5 to less than E9)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

 MP:0020393 increased neuronal precursor proliferation "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Astn2ridge/Astn2ridge,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018672 Copz2 / Q9JHH9 / Coatomer subunit zeta-2 / Q9P299* / coatomer protein complex subunit zeta 2*  / complex
 ENSMUSG00000026553 Copa / Q8CIE6 / Coatomer subunit alpha Xenin Proxenin / P53621* / coatomer protein complex subunit alpha*  / complex
 ENSMUSG00000024870 Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*  / reaction / complex
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / reaction / complex
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000032096 Arcn1 / Q5XJY5 / Coatomer subunit delta / P48444* / archain 1*  / complex
 ENSMUSG00000060992 Copz1 / P61924 / Coatomer subunit zeta-1 / P61923* / coatomer protein complex subunit zeta 1*  / complex
 ENSMUSG00000030058 Copg1 / Q9QZE5 / Coatomer subunit gamma-1 / Q9Y678* / coatomer protein complex subunit gamma 1*  / complex
 ENSMUSG00000025607 Copg2 / Q9QXK3 / Coatomer subunit gamma-2 / Q9UBF2* / coatomer protein complex subunit gamma 2*  / complex
 ENSMUSG00000030754 Copb1 / Q9JIF7 / Coatomer subunit beta / P53618* / coatomer protein complex subunit beta 1*  / complex
 ENSMUSG00000055681 Cope / O89079 / Coatomer subunit epsilon / O14579* / coatomer protein complex subunit epsilon*  / complex






 

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