Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000065	abnormal bone marrow cavities	"absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000097	short maxilla	"reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000103	nasal bone hypoplasia	"reduced cell number in the bone which forms the nasal bridge" [J:53370]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000104	abnormal sphenoid bone morphology	"malformed irregularly shaped bone of the base of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0000120	malocclusion	"perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000164	abnormal cartilage development	"anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000276	right ventricle hypertrophy	"increased size of the right ventricle" [J:33629]	Show Allelic Composition: Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe,Myl2^tm1(cre)Krc/Myl2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1Shh Genetic Background: involves: 129P2/OlaHsd
MP:0000299	failure of endocardial cushion closure	"failure of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [J:29971]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0000440	domed skull		Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000457	maxilla hypoplasia	"arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0000552	abnormal radius morphology	"malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0000608	dissociated hepatocytes	"disorganization of cohesive hepatocyte structure" [J:23170]	Show Allelic Composition: Cacna1g^tm1Stl/Cacna1g^tm1Stl,Tg(Kcnc2-cre)K128Stl/0 Genetic Background: involves: C57BL/6
MP:0000822	abnormal brain ventricle morphology	"malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL
MP:0000825	dilated lateral ventricles	"increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]	Show Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi
MP:0001566	hyperphosphatemia	"abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gipc3^{ahl5-Black Swiss}/Gipc3^{ahl5-Black Swiss},Ahl6^{Black Swiss}/Ahl6^{Black Swiss} Genetic Background: involves: Black Swiss * CAST/EiJ
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0001711	abnormal placenta		Show Allelic Composition: Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0001712	abnormal placental development	"malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6
MP:0001784	abnormal fluid regulation	"anomalous control of intracellular and/or extracellular fluid " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ercc1^tm1Dwm/Ercc1⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^m1Bei/Pkd1^m1Bei Genetic Background: involves: A/J * FVB/N Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129/Sv * Black Swiss Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm3.1Jzh/Pkd1^tm3.1Jzh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Bdgz/Pkd1^tm1Bdgz Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1Shh Genetic Background: involves: 129P2/OlaHsd
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129/Sv * Black Swiss Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abhd5^tm1Rze/Abhd5^tm1Rze,Tg(Ckmm-cre)5Khn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Ggt1-cre)M3Egn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Pkhd1-cre)1Igr/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tg(TRP53R72P)7Dgj/0,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background:* involves: 129S2/SvPas * FVB Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Djmp/Pkd1^tm1Djmp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm1.1Bol/Pkd1^tm1.1Bol Genetic Background: Not Specified Allelic Composition: Pkd1^tm2.1Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.1Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.1Bol/Pkd1^tm2.1Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.1Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.1Bol/Pkd1^tm3.1Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0002189	abnormal myocardial trabeculae morphology	"malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0002192	hydrops fetalis	"an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002260	abnormal thyroid cartilage morphology	"any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0002625	left ventricle hypertrophy	"increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe,Myl2^tm1(cre)Krc/Myl2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe,Myl2^tm1(cre)Krc/Myl2⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0002657	chondrodystrophy	"abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm1Bdgz/Pkd1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Tg(Pkd1)39Mtru/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA/J * SJL
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0002904	increased circulating parathyroid hormone level	"greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0002928	abnormal bile duct morphology	"malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003068	enlarged kidney	"larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^m1Bei/Pkd1^m1Bei Genetic Background: involves: A/J * FVB/N Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1⁺,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)
MP:0003231	abnormal placental vasculature	"malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Pkd2^tm1.1Tjwt/Pkd2^tm1.2Tjwt,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0003253	bile duct dilation	"abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0003254	bile duct inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003266	biliary cysts	"the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
MP:0003325	decreased liver function	"reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003327	liver cysts	"abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Pkd1^tm2Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm1Bdgz/Pkd1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Pkd2^tm2Som/Pkd2⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003334	pancreatic fibrosis	"invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003336	pancreatic cysts	"the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Il10^tm1Roer/Il10^tm1Roer,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: Not Specified Allelic Composition: Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm2Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Bdgz/Pkd1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1Bdgz/Pkd1^tm1Bdgz Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0003338	pancreatic lipomatosis	"an accumulation of abnormally localized or tumor-like fat in the pancreas" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0003420	delayed intramembranous bone ossification	"late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/? Genetic Background: involves: 129P2/OlaHsd * CD-1 Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129P2/OlaHsd
MP:0003432	increased activity of parathyroid	"increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0003450	enlarged pancreas	"increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^m1Bei/Pkd1^m1Bei Genetic Background: involves: A/J * FVB/N
MP:0003602	renal hamartoma		Show Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^m1Bei/Pkd1^m1Bei Genetic Background: involves: A/J * FVB/N Allelic Composition: Pkd1^tm1Djmp/Pkd1^tm1Djmp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: Not Specified Allelic Composition: Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: 129S4/SvJae * FVB Allelic Composition: Pkd1^tm2Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.1Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm1Bdgz/Pkd1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm1Bdgz/Pkd1^tm1Bdgz Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Nek8^jck/Nek8⁺,Pkd1^tm1Bdgz/Pkd1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Pkd2^tm2Som/Pkd2⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Pkhd1-cre)1Igr/0 Genetic Background: involves: C57BL/6 * SJL Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1Shh Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129P2/OlaHsd
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm2Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1⁺,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0003985	renal fibrosis	"formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0004020	polyhydramnios	"abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129/Sv * Black Swiss Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm3.1Jzh/Pkd1^tm3.1Jzh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0004044	aortic dissection	"a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Djmp/Pkd1^tm1Djmp Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004153	increased renal tubule apoptosis	"increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Ggt1-cre)M3Egn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0004380	short frontal bone	"reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004451	short presphenoid bone	"reduced length of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004860	dilated kidney collecting duct	"stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
MP:0004950	abnormal brain vasculature	"any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0004967	abnormal kidney epithelium morphology	"any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N
MP:0005108	abnormal ulna morphology	"malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL
MP:0005220	abnormal exocrine pancreas morphology	"malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0005297	spina bifida occulta	"common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0005328	abnormal circulating creatinine level	"anomalous blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pkd1^tm1Hung/Pkd1^tm1Hung Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB) Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1⁺,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm2Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1⁺,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0005587	abnormal Meckel s cartilage morphology	"structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0006207	embryonic lethality during organogenesis	"death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pkd1^tm1Som/Pkd1⁺ Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0006278	aortic aneurysm	"protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Djmp/Pkd1^tm1Djmp Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006322	abnormal perichondrium morphology	"any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0006357	abnormal circulating mineral level	"anomalous concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0008395	abnormal osteoblast differentiation	"atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm3.1Jzh/Pkd1^tm3.1Jzh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Ggt1-cre)M3Egn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ Allelic Composition: Pkd1^tm1Gztn/Pkd1^tm1Gztn,Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Pkd1^b2b1585Clo/Pkd1^b2b1585Clo Genetic Background: C57BL/6J-Pkd1^b2b1585Clo Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1⁺,Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Tg(Pkd1)39Mtru/0 Genetic Background:* involves: 129/Sv * C57BL/6J * CBA/J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm2Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2⁺ Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL Allelic Composition: Pkd1^tm1.1Pcha/Pkd1⁺,Pkd2^tm1Som/Pkd2^tm2Som Genetic Background: involves: 129 * 129/Sv * C57BL/6 * C57BL/6J * SJL
MP:0009050	dilated proximal convoluted tubules	"stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009144	dilated pancreatic duct	"an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0009145	abnormal pancreatic acinus morphology	"any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0009164	exocrine pancreas atrophy	"wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0009168	decreased pancreatic islet number	"reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Jzh/Pkd1⁺ Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0009495	abnormal common bile duct morphology	"any structural anomaly of the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: B6.129S6-Pkd1^tm1.1Fqi
MP:0009644	uremia	"an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0009760	abnormal mitotic spindle	"an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]	Show Allelic Composition: Rab38^em1Rkuhn/Rab38^em1Rkuhn Genetic Background: involves: C57BL/6JCrl * FVB/NCrl
MP:0010029	abnormal basicranium morphology	"any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0010585	abnormal conotruncal ridge morphology	"any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0010607	common atrioventricular valve	"the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0010656	thick myocardium	"increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0010962	decreased compact bone mass		Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm2Som/Pkd1^tm2.1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: C57BL/6 * ICR * SJL Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm3.1Bol,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac * SJL Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129P2/OlaHsd
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Pkd1^tm3.1Jzh/Pkd1^tm3.1Jzh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c) Allelic Composition: Pkd1^tm1Ggg/Pkd1⁺,Pkhd1^tm1.1Ggg/Pkhd1^tm1.1Ggg Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm2.1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2.1Ggg Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129/Sv * Black Swiss Allelic Composition: Pkd1^tm1.2Djmp/Pkd1^tm1.2Djmp Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Pkd1^tm1.2Bol/Pkd1^tm1.2Bol Genetic Background: Not Specified Allelic Composition: Pkd1^tm1Fqi/Pkd1^tm1Fqi Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: Not Specified Allelic Composition: Pkd1^tm1Maa/Pkd1^tm1Maa Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Bdgz/Pkd1^tm1Bdgz Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Pkd1^tm2.2Bol/Pkd1^tm2.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac Allelic Composition: Pkd1^tm3.2Bol/Pkd1^tm3.2Bol Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm3.1Jzh/Pkd1^tm3.1Jzh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011108	partial embryonic lethality during organogenesis	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm1Som/Pkd1^tm1Som Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1Shh Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Pkd1^tm2Jzh/Pkd1^tm2Jzh Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg,Meox2^tm1(cre)Sor/Meox2⁺ Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor
MP:0011167	abnormal adipose tissue development	"anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0011307	kidney medulla cysts	"abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0011344	abnormal loop of Henle ascending limb thick segment morphology	"any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule" [MGI:anna]	Show Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
MP:0011368	increased kidney apoptosis	"increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Sugt1^{Gt(RRS405)Byg}/Sugt1⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0011440	increased kidney cell proliferation	"increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Pkd1^tm1.1Djmp/Pkd1^tm1.2Djmp,Tg(Cdh16-cre/ERT2)F427Djmp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NCrl * FVB/N Allelic Composition: Pkd1^tm1.2Djmp/Pkd1⁺ Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Nes-cre)Wme/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Prkcsh^tm1Som/Prkcsh^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL Allelic Composition: Pkd1^tm1Som/Pkd1⁺,Sec63^tm1Som/Sec63^tm1Som,Tg(Cdh16-cre)91Igr/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL
MP:0011711	decreased osteoblast differentiation		Show Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0011744	abnormal kidney epithelial cell primary cilium physiology	"any functional anomaly of the non-motile primary cilia found on renal epithelial cells and thought to act as a mechanical sensor to detect renal tubular fluid; impaired mechanical response of primary cilia to physiological fluid flow, or abnormalities in intracellular Ca2+ increase in response to fluid stress may alter renal (tubular) cell proliferation and differentiation and lead to renal cyst formation" [MGI:anna]	Show Allelic Composition: Pkd1^tm1Jzh/Pkd1^tm1Jzh Genetic Background: either: (involves: 129S4/SvJae * C57BL/6) or (involves: 129S4/SvJae * BALB/c)
MP:0012172	abnormal amniotic fluid composition	"any alteration in the expected chemical makeup of the watery liquid within the amnion that surrounds and cushions a growing fetus; normally, early in gestation, amniotic fluid is similar to maternal plasma, mainly water with electrolytes, and later in gestation, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid" [MGI:anna]	Show Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm1Ggg Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)
MP:0014101	decreased chondrocyte proliferation	"decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0020382	increased kidney epithelial cell primary cilium length	"increased length of the cilia on cells of the renal tubule or collecting duct" [PMID:19515853, RGD:slaulederkind]	Show Allelic Composition: Pkd1^tm1Shh/Pkd1^tm1.1Pcha Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0030438	increased osteoblast proliferation	"increase in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]	Show Allelic Composition: Pkd1^tm2Ggg/Pkd1^tm2Ggg,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1 Allelic Composition: Pkd1^tm2Ggg/Pkd1⁺,Tg(Col1a1-cre)1Bek/0 Genetic Background: involves: 129S4/SvJae * CD-1
MP:0030444	premature cranial synchondrosis closure	"early fusion or ossification of one or more cranial base synchondroses relative to age- and gender-matched controls; can lead to midface hypoplasia, as seen in patients with specific forms of syndromic craniosynostosis" [PMID:24480760]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,Tg(Col2a1-cre)10Amc/0 Genetic Background: involves: 129P2/OlaHsd
MP:0030445	abnormal sphenooccipital synchondrosis	"any anomaly in the development of the cartilaginous joint (growth center) between the basioccipital and basisphenoid bones that is an important driver of facial and cranial base growth; sphenooccipital synchondroses are among the last to fuse and may remain patent until early adulthood" [https://www.merriam-webster.com/medical/spheno-occipital%20synchondrosis, PMID:22777037, PMID:24255553]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0030446	premature sphenooccipital synchondrosis closure	"early closure or ossification of the sphenooccipital synchondrosis relative to age- and gender-matched controls; premature fusion has been associated with midface hypoplasia in animal models and patients with specific forms of syndromic craniosynostosis" [PMID:24406578, PMID:24480760]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
MP:0030447	abnormal presphenoid synchondrosis	"any anomaly in the development of the cartilaginous joint (growth center) between the presphenoid and basisphenoid bones of the skull base" [PMID:23179633]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0030448	premature presphenoid synchondrosis closure	"early closure or ossification of the presphenoid synchondrosis relative to age- and gender-matched controls" [MGI:anna]	Show Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Pkd1^tm3Jzh/Pkd1^tm3Jzh Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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